过去十年中新出现的中枢神经系统真菌感染:文献综述。

IF 3.4 Q2 INFECTIOUS DISEASES
Rita Lino, André Rodrigues Guimarães, Estela Sousa, Mariana Azevedo, Lurdes Santos
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引用次数: 0

摘要

导言:影响中枢神经系统(CNS)的侵袭性真菌感染是全球关注的主要健康问题,死亡率很高。其发病率的增加主要是由于易受感染的免疫力低下人群的增加、环境因素的变化以及更准确诊断方法的发展。本文旨在找出导致中枢神经系统感染的真菌病原体,这些病原体最近刚刚出现或有可能在不久的将来成为新出现的病原体,以及它们的临床特征,包括这些真菌包括:白色念珠菌(Candida auris)、三代孢子菌(Trichosporon spp.)、布氏酵母菌(Blastomyces spp.)、孢子丝菌(Sporothrix spp.)、Talaromyces marneffei、Lomentospora prolificans 和 Scedosporium spp.:方法:对 PubMed 上过去十年的文献进行回顾,以确定由这些真菌引起的中枢神经系统感染:结果:综述发现了 10 例由球孢子菌引起的病例、5 例由三代孢子菌引起的病例、82 例由布氏杆菌引起的病例、36 例由孢子丝菌引起的病例、21 例由马恩菲球孢子菌引起的病例、22 例由多发性洛门托孢子菌引起的病例和 42 例由孢子丝菌引起的病例:这些疾病的确切发病率仍难以确定,但其明显上升的趋势突出表明,迫切需要改进针对中枢神经系统真菌病原体的诊断、治疗和管理策略,以改善这些威胁生命的感染的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emerging Fungal Infections of the Central Nervous System in the Past Decade: A Literature Review.

Introduction: Invasive fungal infections affecting the central nervous system (CNS) are a major health concern worldwide associated with high mortality rates. Their increased incidence is largely due to an increase in the vulnerable immunocompromised population, changing environmental factors, and development of more accurate diagnostic methods. The aim of this article is to identify fungal causes of CNS infections that are recently emerging or have the potential to become emerging pathogens in the near future, as well as their clinical characteristics, including: Candida auris, Trichosporon spp., Blastomyces spp., Sporothrix spp., Talaromyces marneffei, Lomentospora prolificans, and Scedosporium spp.

Methods: A review of the literature in PubMed in the last ten years was conducted to identify central nervous system infections caused by each of these fungi.

Results: The review identified 10 cases caused by C. auris, 5 cases by Trichosporon spp., 82 cases by Blastomyces spp., 36 cases by Sporothrix spp., 21 cases by T. marneffei, 22 cases by Lomentospora prolificans, and 42 cases by Scedosporium spp.

Discussion: The exact burden of these diseases remains difficult to ascertain, but their apparent rise underscores the urgent need for improved diagnostic, treatment, and management strategies against CNS fungal pathogens to improve outcomes against these life-threatening infections.

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来源期刊
Infectious Disease Reports
Infectious Disease Reports INFECTIOUS DISEASES-
CiteScore
5.10
自引率
0.00%
发文量
82
审稿时长
11 weeks
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