新型 N-芳基苯并[h]喹唑啉-2-胺的合成和细胞毒性研究。

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI:10.3762/bjoc.20.218

Battini Veeraiah, Kishore Ramineni, Dabbugoddu Brahmaiah, Nangunoori Sampath Kumar, Hélène Solhi, Rémy Le Guevel, Chada Raji Reddy, Frédéric Justaud, René Grée

引用次数: 0

摘要

在本文中，我们报告了一种新型 N-芳基苯并[h]喹唑啉-2-胺的简短高效合成方法。我们制备了一个由 19 个具有代表性的实例组成的重点文库，并对这些实例进行了细胞毒性测试，结果显示，其中几个分子对 8 种癌症细胞株具有吸引力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis and cytotoxicity studies of novel N-arylbenzo[h]quinazolin-2-amines.

In this paper, we report a short and efficient synthesis of novel N-arylbenzo[h]quinazoline-2-amines. We have prepared a focused library of nineteen representative examples which have been submitted to cytotoxicity assays against a representative panel of eight cancer cell lines and several molecules gave attractive results in this area.

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.