麦饭石 "大米 "和 "非大米 "部分之间的元素差异及其健康风险评估。

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2024-10-13 DOI:10.1016/j.jtemb.2024.127550

Liu Zhou , Zheng Liu , Yulu Ma , Fang Fang , Xilong Qian , Yanqiong Pan , Ying Zhang , Xiuxiu Wang , Jing Zhao , Shengjin Liu

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引用次数: 0

摘要

背景：麦饭石是一种中药矿物，最早见于宋代（960-1279 年）。历史记载表明，麦饭石具有解毒化瘀、祛除坏死组织、利尿消结、延年益寿等多方面的治疗功效。麦饭石中的元素浓度会因产地、不同部位而异，从而影响其在不同领域的应用效果。因此，对麦饭石中的元素进行了分析，并随后进行了健康风险评估。这为麦饭石的质量控制和应用安全提供了重要依据：本研究采用电感耦合等离子体质谱法（ICP-MS）和电感耦合等离子体光发射光谱法（ICP-OES），对麦饭石样本中的 60 种元素（见附录 1）进行定量评估。根据检测结果，采用化学计量学方法评估不同来源和地点的元素浓度特征和差异。此外，还对不同产地和不同部位的麦饭石进行了初步的健康风险评估：结果：我们为麦饭石中的元素建立了指纹图谱，显示出值得称赞的相似性。分层聚类分析（HCA）的结果与主聚类分析的结果相吻合。与主成分分析（PCA）的结果相吻合，共同揭示了不同产地和用途的麦饭石样本之间元素差异的系统轮廓。研究还发现，在麦饭石的不同部位，Al、Ga、Be、Hf、Na、Sn、Ti、Zr、Gd、Tb、Sr、Pb、Ce、Ba 和其他元素的浓度存在差异。虽然所有样本中的镉、砷和铜含量都在《中国药典》规定的允许范围内，但大多数样本中的铅浓度都超过了这些标准，尽管 "非大米 "部分的铅浓度略高。对有益元素和有害元素的评估表明，麦饭石的 "非大米 "部分具有更优越的质量属性。此外，麦饭石中稀土元素的总体浓度大大低于人类日常食用的既定下限，没有直接证据表明会对健康造成任何不利影响：本研究为麦饭石在临床使用中的质量控制和安全性评估提供了依据。

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The elemental variance between the "rice" and "non-rice" portions of Maifanitum and its health risk assessment

Background

Maifanitum, a mineral used in Chinese medicine, was first documented during the Song Dynasty (960–1279). Historical records suggest its multifaceted therapeutic properties, including detoxification and stasis resolution, necrosis removal and tissue regeneration, diuretic and calculi dissolution and prolonging life. The concentration of elements in Maifanitum may vary depending on its origin, different parts, which can affect its effectiveness in different fields of applications. Therefore, the analysis of elements in Maifanitum and the subsequent health risk assessment have been conducted. This provides an important basis for the quality control and application safety of Maifanitum.

Method

The analytical techniques employed in this study are inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES), utilized for the quantitative assessment of 60 elements (Refer to Appendix 1) within Maifanitum samples. Based on the test results, chemometric methods are employed to evaluate the characteristics and differences in elemental concentration from different sources and locations. Additionally, a preliminary health risk assessment is conducted for Maifanitum from different origins and various parts.

Results

We have established a fingerprint of the elements within Maifanitum, demonstrating a commendable level of similarity. The findings from hierarchical cluster analysis（HCA） corroborated with those from principal component analysis (PCA), collectively unveiling a systematic profile of elemental disparities between Maifanitum samples of diverse origins and applications. It also revealed that there are differences in the concentration of Al, Ga, Be, Hf, Na, Sn, Ti, Zr, Gd, Tb, Sr, Pb, Ce, Ba and other elements in different parts of Maifanitum. While Cd, As, and Cu levels in all samples were within the permissible limits as defined by the Chinese Pharmacopeia, Pb concentrations in the majority of samples were found to surpass these standards, albeit slightly in the ''non-rice'' fraction. The assessment of both beneficial and deleterious elements indicates that the ''non-rice'' fraction of Maifanitum possesses superior quality attributes. Moreover, the overall concentration of rare earth elements in Maifanitum is substantially below the established lower threshold for daily human consumption, with no immediate evidence suggesting any adverse health risks.

Conclusion

This study provides a basis for the quality control and safety evaluation of Maifanitum in clinical use.

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.