衰老的免疫代谢根源

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2024-10-26 DOI:10.1016/j.coi.2024.102498

Pierpaolo Ginefra , Helen C Hope , Girieca Lorusso , Patrizia D’Amelio , Nicola Vannini

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引用次数: 0

摘要

衰老是多种慢性疾病的最大风险因素之一，并伴随着细胞和器官功能的逐渐衰退。最近的研究强调，新陈代谢的变化是衰老过程中机体功能失调的主要驱动因素之一，而新陈代谢的变化又会严重恶化免疫细胞的性能和功能。事实上，免疫系统功能失调已被证明会对机体产生多重影响，加速个体的整体衰老过程。内在和外在因素是造成这种新陈代谢变化的原因。了解这些不同因素的贡献、调节和联系对于理解衰老过程和开发缓解与年龄相关的免疫力下降的方法至关重要。在此，我们将描述发生在细胞和系统水平的代谢紊乱。我们特别强调了新陈代谢与免疫衰老之间的相互作用，并介绍了保护免疫功能和促进健康寿命的新型干预措施。

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The immunometabolic roots of aging

Aging is one of the greatest risk factors for several chronic diseases and is accompanied by a progressive decline of cellular and organ function. Recent studies have highlighted the changes in metabolism as one of the main drivers of organism dysfunctions during aging and how that strongly deteriorate immune cell performance and function. Indeed, a dysfunctional immune system has been shown to have a pleiotropic impact on the organism, accelerating the overall aging process of an individual.

Intrinsic and extrinsic factors are responsible for such metabolic alterations. Understanding the contribution, regulation, and connection of these different factors is fundamental to comprehend the process of aging and develop approaches to mitigate age-related immune decline. Here, we describe metabolic perturbations occurring at cellular and systemic levels. Particularly, we emphasize the interplay between metabolism and immunosenescence and describe novel interventions to protect immune function and promote health span.

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.