含糖饮料和人工甜味饮料的累积摄入量与冠状动脉钙化进展之间的关系：CARDIA研究的启示

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-10-10 DOI:10.1016/j.numecd.2024.09.017

Lingqu Zhou , Qi Guo , Junjie Wang , Zirui Zhou , Yinyin Zhang

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引用次数: 0

摘要

背景和目的：本研究利用 "青年冠状动脉风险发展 "研究的数据，探讨了青年期人工甜饮料（ASB）和含糖饮料（SSB）的累积摄入量与中年期冠状动脉钙化（CAC）进展之间的关系：我们纳入了 2466 名在第 15、20 和 25 年随访时通过计算机断层扫描测量 CAC 的参与者。在基线和第 7 年时，使用 CARDIA 饮食史评估饮食摄入量。对累计平均饮料摄入量进行计算和分类。经人口统计学、生活方式和心血管风险因素调整的多变量 Cox 回归模型评估了饮料摄入量与 CAC 进展之间的关系。在纳入的参与者中，1107 人（44.9%）为男性，1439 人（58.4%）为白人，平均年龄为 40.4 岁，标准差为 3.5 岁。在 9.2±1.8 年的随访中，715 名参与者的 CAC 发生了进展。ASBs累积摄入量越高，CAC进展风险越大，ASBs摄入量低和摄入量高的危险比（95%CI，P值）分别为1.35（1.14，1.60；P 2份/天的SSBs的CAC进展风险高出37%（HR 1.37，95% CI 1.14-1.64，P 结论：ASBs累积摄入量越高，CAC进展风险越大：青壮年长期饮用饮料，尤其是 ASB 与 CAC 进展风险增加有关。

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Association between cumulative intake of sugar-sweetened and artificially sweetened beverages and progression of coronary calcification: Insights from the CARDIA study

Background and aims

This study investigates the relationship between the cumulative intake of artificially sweetened beverages (ASBs) and sugar-sweetened beverages (SSBs) during young adulthood and the progression of coronary artery calcium (CAC) by midlife, using data from the Coronary Artery Risk Development in Young Adults study.

Methods and results

We included 2,466 participants with CAC measurement via computed tomography at the 15th, 20th, and 25th year follow-ups. Dietary intake was assessed using the CARDIA Diet History at baseline and years 7. Cumulative average beverage intake was calculated and categorized. Multivariable Cox regression models adjusted for demographic, lifestyle, and cardiovascular risk factors assessed associations between beverages consumption and CAC progression. Among the included participants, 1107 (44.9 %) were male, 1439 (58.4 %) were white, and the average age was 40.4 years with a standard deviation of 3.5 years. Over a 9.2±1.8-year follow-up, CAC progression was recorded in 715 participants. Higher cumulative ASBs intake was associated with increased CAC progression risk, with hazard ratios (95%CI, P-value) for low and high ASBs consumption being 1.35 (1.14, 1.60; P < 0.001) and 1.54 (1.15, 2.07; P < 0.001) compared to non-consumers. Participants consuming >2 servings/day of SSBs had a 37 % higher CAC progression risk (HR 1.37, 95 % CI 1.14–1.64, P < 0.001). However, no significant association was found between SSB consumption and CAC progression after adjusting for confounders.

Conclusions

Prolonged consumption of beverages, especially ASBs, in young adults is linked to an increased risk of CAC progression.

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来源期刊

Nutrition Metabolism and Cardiovascular Diseases 医学-内分泌学与代谢

CiteScore

6.80

自引率

2.60%

发文量

332

审稿时长

57 days

期刊介绍： Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.