自然杀伤细胞及其新陈代谢在 HIV-1 感染中的作用

IF 3.8 3区医学 Q2 VIROLOGY

Viruses-Basel Pub Date : 2024-10-09 DOI:10.3390/v16101584

Kewreshini K Naidoo, Marcus Altfeld

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引用次数: 0

摘要

自然杀伤（NK）细胞是一种多方面的先天效应细胞，对抗病毒免疫有重要影响，目前已描述了几种可调节 HIV-1 感染和病毒控制的保护性 NK 细胞特征。慢性 HIV-1 感染会导致 NK 细胞受损，这与新陈代谢失调有关。针对细胞免疫代谢的治疗方法是扭转 HIV 感染者 NK 细胞功能缺陷的潜在新型干预措施。

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The Role of Natural Killer Cells and Their Metabolism in HIV-1 Infection.

Natural killer (NK) cells are multifaceted innate effector cells that critically influence antiviral immunity, and several protective NK cell features that modulate HIV-1 acquisition and viral control have been described. Chronic HIV-1 infection leads to NK cell impairment that has been associated with metabolic dysregulations. Therapeutic approaches targeting cellular immune metabolism represent potential novel interventions to reverse defective NK cell function in people living with HIV.

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来源期刊

Viruses-Basel VIROLOGY-

CiteScore

7.30

自引率

12.80%

发文量

2445

审稿时长

1 months

期刊介绍： Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.