构建基于外周血体征的预测模型,以区分传染性单核细胞增多症和慢性活动性 EBV 感染。

IF 1.4 4区 医学 Q4 INFECTIOUS DISEASES
Jin Hua Yuan, Chong Jie Pang, Shuang Long Yuan
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引用次数: 0

摘要

目的建立一个基于外周血体征的预测模型,以区分传染性单核细胞增多症和慢性活动性EB病毒感染:收集2018年12月至2022年9月期间在天津医科大学总医院住院确诊的60例IM患者(IM组)和20例CAEBV感染患者(CAEBV组)的回顾性数据。采用的分析方法为单变量和LASSO(最小绝对收缩和选择算子)逻辑回归:单变量分析显示,IM和CAEBV感染患者的临床表现有重叠和交叉,如发热、咽痛、淋巴结肿大、肝脾肿大等,与外周血炎症反应相比,CAEBV感染患者的炎症反应更为严重。随后,通过 LASSO 逻辑回归模型筛选出九种生物标志物--HGB、淋巴细胞计数、淋巴细胞百分比、ALB、纤维蛋白原、CRP、IFN-、IL-6 和 EBV-DNA 负载,作为判别模型:我们的研究为根据外周血指标的重要性和可用性使用 LASSO 逻辑回归模型诊断 IM 和 CAEBV 感染奠定了坚实的基础。感染 CAEBV 的患者需要尽早就医。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Constructing a predictive model based on peripheral blood signs to differentiate infectious mononucleosis from chronic active EBV infection.

Objective: To develop a prediction model based on peripheral blood signs to distinguish between infectious mononucleosis and chronic active EBV infection.

Methods: Retrospective data was collected for 60 patients with IM (IM group) and 20 patients with CAEBV infection (CAEBV group) who were hospitalized and diagnosed at the General Hospital of Tianjin Medical University between December 2018 and September 2022. The analyses used were univariate and LASSO (least absolute shrinkage and selection operator) logistic regression.

Results: Univariate analyses revealed that both IM and CAEBV-infected patients displayed overlapping and intersecting clinical manifestations, such as fever, sore throat, enlarged lymph nodes, and enlargement of the liver and spleen, and that in contrast to inflammatory responses in peripheral blood, CAEBV-infected patients had more severe inflammatory responses. Nine biomarkers-HGB, lymphocyte count, percentage of lymphocytes, ALB, fibrinogen, CRP, IFN-, IL-6, and EBV-DNA load-were subsequently selected by LASSO logistic regression modeling to serve as discriminatory models.

Conclusions: Our investigation offers a solid foundation for diagnosing IM and CAEBV infection using the LASSO logistic regression model based on the significance and availability of peripheral blood indicators. Infected patients with CAEBV require early medical attention.

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来源期刊
CiteScore
3.70
自引率
5.30%
发文量
239
审稿时长
4-8 weeks
期刊介绍: The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.
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