2020 年至 2022 年加拿大阿尔伯塔省南部产志贺毒素大肠杆菌 (STEC) 的临床结果和毒性因素。

IF 3.3 3区医学 Q2 MICROBIOLOGY

Pathogens Pub Date : 2024-09-24 DOI:10.3390/pathogens13100822

Heather Glassman, Vivien Suttorp, Theron White, Kim Ziebell, Ashley Kearney, Kyrylo Bessonov, Vincent Li, Linda Chui

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引用次数: 0

摘要

产志贺毒素大肠杆菌（STEC）可导致人类，尤其是幼儿患上严重的临床疾病。最近的进步使得测序技术更加普及。我们试图利用全基因组测序数据来确定 2020-2022 年间提交给我们实验室的南阿尔伯塔省所有临床分离物中是否存在已知毒力因子，并将这些毒力因子与通过病历审查获得的临床结果联系起来。总体而言，大多数 HUS 和住院患者都是 O157:H7 血清型患者，HUS 病例主要发生在幼儿身上。O157:H7血清型和非O157血清型的致病因子频率不同。在 O157:H7 病例中，某些致病因子（包括 espP、espX1 和 katP）在 HUS 病例中更为常见。由于样本数量太少，无法确定统计意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical Outcomes and Virulence Factors of Shiga Toxin-Producing Escherichia coli (STEC) from Southern Alberta, Canada, from 2020 to 2022.

Shiga toxin-producing Escherichia coli (STEC) can cause severe clinical disease in humans, particularly in young children. Recent advances have led to greater availability of sequencing technologies. We sought to use whole genome sequencing data to identify the presence or absence of known virulence factors in all clinical isolates submitted to our laboratory from Southern Alberta dated 2020-2022 and correlate these virulence factors with clinical outcomes obtained through chart review. Overall, the majority of HUS and hospitalizations were seen in patients with O157:H7 serotypes, and HUS cases were primarily in young children. The frequency of virulence factors differed between O157:H7 and non-O157 serotypes. Within the O157:H7 cases, certain virulence factors, including espP, espX1, and katP, were more frequent in HUS cases. The number of samples was too low to determine statistical significance.

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来源期刊

Pathogens Medicine-Immunology and Allergy

CiteScore

6.40

自引率

8.10%

发文量

1285

审稿时长

17.75 days

期刊介绍： Pathogens (ISSN 2076-0817) publishes reviews, regular research papers and short notes on all aspects of pathogens and pathogen-host interactions. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodical details must be provided for research articles.