迷迭香酸的化学保护荷尔蒙作用。

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI:10.1515/med-2024-1065

Edward J Calabrese, Peter Pressman, A Wallace Hayes, Gaurav Dhawan, Rachna Kapoor, Evgenios Agathokleous, Linda A Baldwin, Vittorio Calabrese

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引用次数: 0

摘要

迷迭香酸是一种存在于多种水果和蔬菜中的多酚类物质，可以以补充剂的形式食用，并因其潜在的化学预防特性而在众多临床试验中接受治疗测试。对迷迭香酸进行了广泛的细胞、整体动物和分子机制研究，发现它具有一系列复杂的多系统生物效应。迷迭香酸诱导的荷尔蒙剂量反应非常普遍，在许多生物模型和细胞类型中都会出现，涉及广泛的终点。因此，本文首次评估了迷迭香酸诱导的荷尔蒙浓度/剂量反应、其定量特征、机理基础、外推强度/局限性及其对生物医学、临床和公共卫生的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The chemoprotective hormetic effects of rosmarinic acid.

Rosmarinic acid is a polyphenol found in numerous fruits and vegetables, consumed in supplement form, and tested in numerous clinical trials for therapeutic applications due to its putative chemopreventive properties. Rosmarinic acid has been extensively studied at the cellular, whole animal, and molecular mechanism levels, presenting a complex array of multi-system biological effects. Rosmarinic acid-induced hormetic dose responses are widespread, occurring in numerous biological models and cell types for a broad range of endpoints. Consequently, this article provides the first assessment of rosmarinic acid-induced hormetic concentration/dose responses, their quantitative features, mechanistic foundations, extrapolative strengths/limitations, and their biomedical, clinical, and public health implications.

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.