肝病中的肠肝轴：从基础科学到临床治疗（综述）。

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Molecular medicine reports Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI:10.3892/mmr.2024.13375

Jianpeng Wang, Xinyi Wang, Enba Zhuo, Bangjie Chen, Shixin Chan

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引用次数: 0

摘要

一些肝脏疾病的发病率有所上升。肠道微生物群在肝炎、肝硬化和肝癌的发病机制中发挥着作用。肠道微生物群被认为是 "新的虚拟代谢器官"。肠道微生物群与肝脏之间的相互作用被称为 "肠肝轴"。肠肝轴为肝病发展机制提供了一个新的研究方向。本综述讨论了肠道-肝轴的作用，以及如何通过新型疗法针对常见肝病进行治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gut‑liver axis in liver disease: From basic science to clinical treatment (Review).

Incidence of a number of liver diseases has increased. Gut microbiota serves a role in the pathogenesis of hepatitis, cirrhosis and liver cancer. Gut microbiota is considered 'a new virtual metabolic organ'. The interaction between the gut microbiota and liver is termed the gut‑liver axis. The gut‑liver axis provides a novel research direction for mechanism of liver disease development. The present review discusses the role of the gut‑liver axis and how this can be targeted by novel treatments for common liver diseases.

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来源期刊

Molecular medicine reports 医学-病理学

CiteScore

7.60

自引率

0.00%

发文量

321

审稿时长

1.5 months

期刊介绍： Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.