瘤内微生物群:诊断和治疗肝细胞癌的新兴力量。

IF 2.8 4区 医学 Q2 ONCOLOGY
Huanxiang Liu, Jiahao Zhang, Yuye Rao, Shengjie Jin, Chi Zhang, Dousheng Bai
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引用次数: 0

摘要

肝细胞癌(HCC)是世界上发病率最高的癌症之一,其发病率和死亡率逐年上升,而且往往在确诊时已是晚期。手术、化疗和放疗等传统治疗方法疗效有限,因此迫切需要新的诊断和治疗策略。最近的研究发现,瘤内微生物群通过调节炎症、免疫反应和细胞信号通路,对 HCC 的发生、发展和转移有显著影响。瘤内微生物群通过影响肿瘤微环境和改变免疫系统的功能来促进 HCC 的病理过程。本文回顾了HCC中瘤内微生物群的作用机制,并展望了基于瘤内微生物群的HCC治疗策略的未来可能性。这一新兴领域为 HCC 的早期诊断和个性化治疗方法提供了新的见解,同时也具有巨大的临床应用潜力,可改善患者预后,并根据个体肿瘤特征采取相应的干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intratumoral microbiota: an emerging force in diagnosing and treating hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) ranks among the most prevalent types of cancer in the world and its incidence and mortality are increasing year by year, frequently diagnosed at an advanced stage. Traditional treatments such as surgery, chemotherapy, and radiotherapy have limited efficacy, so new diagnostic and treatment strategies are urgently needed. Recent research has discovered that intratumoral microbiota significantly influences the development, progression, and metastasis of HCC by modulating inflammation, immune responses, and cellular signaling pathways. Intratumoral microbiota contributes to the pathologic process of HCC by influencing the tumor microenvironment and altering the function of immune system. This article reviews the mechanism of intratumoral microbiota in HCC and anticipates the future possibilities of intratumoral microbiota-based therapeutic strategies for HCC management. This emerging field provides fresh insights into early diagnosis and personalized approaches for HCC while holding substantial clinical application potential to improve patient outcomes and tailor interventions to individual tumor profiles.

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来源期刊
Medical Oncology
Medical Oncology 医学-肿瘤学
CiteScore
4.20
自引率
2.90%
发文量
259
审稿时长
1.4 months
期刊介绍: Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.
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