作为坏死性小肠结肠炎发病率和严重程度标志物的肠脂肪酸结合蛋白：范围综述》。

IF 1.8 3区医学 Q2 SURGERY

Journal of Surgical Research Pub Date : 2024-10-21 DOI:10.1016/j.jss.2024.09.059

Lourenço Sbragia MD, PhD , Igor José Nogueira Gualberto MD , Jason Xia MD , Rahul Gadde MD , Angela Saulsbery MA , Sophia Hameedi MD , Ana Laura Ferreira Mársico Dalto MD, PhD , Oluyinka O. Olutoye MD, PhD

{"title":"作为坏死性小肠结肠炎发病率和严重程度标志物的肠脂肪酸结合蛋白：范围综述》。","authors":"Lourenço Sbragia MD, PhD , Igor José Nogueira Gualberto MD , Jason Xia MD , Rahul Gadde MD , Angela Saulsbery MA , Sophia Hameedi MD , Ana Laura Ferreira Mársico Dalto MD, PhD , Oluyinka O. Olutoye MD, PhD","doi":"10.1016/j.jss.2024.09.059","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Necrotizing enterocolitis (NEC) is a severe inflammatory disease of the gastrointestinal tract and one of the most common life-threatening emergencies affecting newborns. Intestinal fatty acid–binding protein (I-FABP) has been used as a possible marker of intestinal damage in NEC. We aimed to carry out a scoping review of all publications that explore the role of I-FABP in NEC to inspire new research into the potential utility of I-FABP as a marker of NEC.</div></div><div><h3>Methods</h3><div>We searched for relevant publications using the keywords “necrotizing enterocolitis,” “intestinal fatty acid binding protein,” “NEC,” and “I-FABP” in the National Library of Medicine (PubMed/MEDLINE), Embase, SCOPUS, and Web of Science. Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews was used for reporting findings.</div></div><div><h3>Results</h3><div>We identified 61 relevant articles, which we divided into clinical (<em>n</em> = 47) and experimental (<em>n</em> = 14) groups.</div></div><div><h3>Conclusions</h3><div>I-FABP is a promising marker of NEC, especially for NEC stage 2 and 3. Urinary I-FABP follows the same patterns as serum and plasma I-FABP. The definitive roles of I-FABP in early diagnosis of NEC, differential diagnosis in breast feeding, alimentary intolerance, and screening of surgical NEC need clarification and remain a challenge to investigators.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"303 ","pages":"Pages 613-627"},"PeriodicalIF":1.8000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Intestinal Fatty Acid–Binding Protein as a Marker of Necrotizing Enterocolitis Incidence and Severity: A Scoping Review\",\"authors\":\"Lourenço Sbragia MD, PhD , Igor José Nogueira Gualberto MD , Jason Xia MD , Rahul Gadde MD , Angela Saulsbery MA , Sophia Hameedi MD , Ana Laura Ferreira Mársico Dalto MD, PhD , Oluyinka O. Olutoye MD, PhD\",\"doi\":\"10.1016/j.jss.2024.09.059\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Necrotizing enterocolitis (NEC) is a severe inflammatory disease of the gastrointestinal tract and one of the most common life-threatening emergencies affecting newborns. Intestinal fatty acid–binding protein (I-FABP) has been used as a possible marker of intestinal damage in NEC. We aimed to carry out a scoping review of all publications that explore the role of I-FABP in NEC to inspire new research into the potential utility of I-FABP as a marker of NEC.</div></div><div><h3>Methods</h3><div>We searched for relevant publications using the keywords “necrotizing enterocolitis,” “intestinal fatty acid binding protein,” “NEC,” and “I-FABP” in the National Library of Medicine (PubMed/MEDLINE), Embase, SCOPUS, and Web of Science. Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews was used for reporting findings.</div></div><div><h3>Results</h3><div>We identified 61 relevant articles, which we divided into clinical (<em>n</em> = 47) and experimental (<em>n</em> = 14) groups.</div></div><div><h3>Conclusions</h3><div>I-FABP is a promising marker of NEC, especially for NEC stage 2 and 3. Urinary I-FABP follows the same patterns as serum and plasma I-FABP. The definitive roles of I-FABP in early diagnosis of NEC, differential diagnosis in breast feeding, alimentary intolerance, and screening of surgical NEC need clarification and remain a challenge to investigators.</div></div>\",\"PeriodicalId\":17030,\"journal\":{\"name\":\"Journal of Surgical Research\",\"volume\":\"303 \",\"pages\":\"Pages 613-627\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-10-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Surgical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022480424006073\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Surgical Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022480424006073","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

摘要

简介坏死性小肠结肠炎（NEC）是一种严重的胃肠道炎症性疾病，也是影响新生儿生命的最常见急症之一。肠道脂肪酸结合蛋白（I-FABP）已被用作 NEC 肠道损伤的可能标志物。我们的目的是对所有探讨 I-FABP 在 NEC 中作用的出版物进行一次范围审查，以激发对 I-FABP 作为 NEC 标志物的潜在效用的新研究：我们在美国国家医学图书馆（PubMed/MEDLINE）、Embase、SCOPUS 和 Web of Science 中使用关键词 "坏死性小肠结肠炎"、"肠脂肪酸结合蛋白"、"NEC "和 "I-FABP "搜索相关出版物。报告结果时使用了《系统综述和元分析首选报告项目》的扩展版（SCOPUS）：我们确定了 61 篇相关文章，并将其分为临床组（47 篇）和实验组（14 篇）：结论：I-FABP 是一种很有前景的 NEC 标志物，尤其适用于 NEC 2 期和 3 期。尿 I-FABP 与血清和血浆 I-FABP 的变化规律相同。I-FABP 在 NEC 早期诊断、母乳喂养鉴别诊断、消化道不耐受和手术 NEC 筛查中的明确作用需要明确，这仍是研究人员面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Intestinal Fatty Acid–Binding Protein as a Marker of Necrotizing Enterocolitis Incidence and Severity: A Scoping Review

Introduction

Necrotizing enterocolitis (NEC) is a severe inflammatory disease of the gastrointestinal tract and one of the most common life-threatening emergencies affecting newborns. Intestinal fatty acid–binding protein (I-FABP) has been used as a possible marker of intestinal damage in NEC. We aimed to carry out a scoping review of all publications that explore the role of I-FABP in NEC to inspire new research into the potential utility of I-FABP as a marker of NEC.

Methods

We searched for relevant publications using the keywords “necrotizing enterocolitis,” “intestinal fatty acid binding protein,” “NEC,” and “I-FABP” in the National Library of Medicine (PubMed/MEDLINE), Embase, SCOPUS, and Web of Science. Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews was used for reporting findings.

Results

We identified 61 relevant articles, which we divided into clinical (n = 47) and experimental (n = 14) groups.

Conclusions

I-FABP is a promising marker of NEC, especially for NEC stage 2 and 3. Urinary I-FABP follows the same patterns as serum and plasma I-FABP. The definitive roles of I-FABP in early diagnosis of NEC, differential diagnosis in breast feeding, alimentary intolerance, and screening of surgical NEC need clarification and remain a challenge to investigators.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Surgical Research 医学-外科

CiteScore

3.90

自引率

4.50%

发文量

627

审稿时长

138 days

期刊介绍： The Journal of Surgical Research: Clinical and Laboratory Investigation publishes original articles concerned with clinical and laboratory investigations relevant to surgical practice and teaching. The journal emphasizes reports of clinical investigations or fundamental research bearing directly on surgical management that will be of general interest to a broad range of surgeons and surgical researchers. The articles presented need not have been the products of surgeons or of surgical laboratories. The Journal of Surgical Research also features review articles and special articles relating to educational, research, or social issues of interest to the academic surgical community.