Angelo Michele Inchingolo, Alessio Danilo Inchingolo, Paola Nardelli, Giulia Latini, Irma Trilli, Laura Ferrante, Giuseppina Malcangi, Andrea Palermo, Francesco Inchingolo, Gianna Dipalma
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引用次数: 0
摘要
牙科再生医学侧重于利用干细胞、生物材料和组织工程（TE）等先进工具修复受损的口腔组织。牙髓和牙周韧带等牙科来源的间充质干细胞（MSCs）因其增殖和分化能力，在组织再生方面显示出巨大潜力。本系统综述遵循PRISMA指南，评估了15项研究，确定了通过支架、分泌物和生物工程方法改善牙科、牙周和骨组织再生的有效策略。主要进展包括使用牙髓干细胞（DPSCs）和牙周韧带干细胞（PDLSCs）来提高细胞活力和控制炎症。此外，药物制剂（如马替林）和生物材料的表面修饰可提高干细胞的粘附性并促进成骨分化。通过整合这些方法，再生医学和 TE 可以优化牙科疗法，提高患者的治疗效果。这篇综述强调了这一领域的潜力和挑战，对当前研究和未来方向进行了批判性评估。
Stem Cells: Present Understanding and Prospects for Regenerative Dentistry.
Regenerative medicine in dentistry focuses on repairing damaged oral tissues using advanced tools like stem cells, biomaterials, and tissue engineering (TE). Mesenchymal stem cells (MSCs) from dental sources, such as dental pulp and periodontal ligament, show significant potential for tissue regeneration due to their proliferative and differentiative abilities. This systematic review, following PRISMA guidelines, evaluated fifteen studies and identified effective strategies for improving dental, periodontal, and bone tissue regeneration through scaffolds, secretomes, and bioengineering methods. Key advancements include the use of dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs) to boost cell viability and manage inflammation. Additionally, pharmacological agents like matrine and surface modifications on biomaterials improve stem cell adhesion and promote osteogenic differentiation. By integrating these approaches, regenerative medicine and TE can optimize dental therapies and enhance patient outcomes. This review highlights the potential and challenges in this field, providing a critical assessment of current research and future directions.
期刊介绍：
Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.
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