甲状腺球蛋白和降钙素测量：误区与未来展望。

IF 3.4 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Endocrinology Pub Date : 2024-12-20 Print Date: 2025-01-01 DOI:10.1530/JOE-24-0156

Amber Mater, Anita Boelen, Annemieke C Heijboer, Jacquelien J Hillebrand

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引用次数: 0

摘要

甲状腺癌是最常见的内分泌癌症。预后取决于癌症的类型和发现时的阶段。治疗包括（半）甲状腺切除术，随后可能会有其他治疗方案。治疗后，患者的血清中内分泌肿瘤标志物甲状腺球蛋白的浓度（分化型癌症）和降钙素原的浓度（髓样甲状腺癌）将受到监测。测量血清中甲状腺球蛋白和降钙素的浓度可能具有挑战性。在这篇综述中，我们将全面概述甲状腺球蛋白和降钙素实验室测量的发展历程，重点介绍（预）分析面临的挑战和克服当前陷阱的潜在方法。

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Thyroglobulin and calcitonin measurements: pitfalls and future perspectives.

Thyroid cancer is the most prevalent endocrine cancer, and the prognosis depends on the type and stage of cancer at the time of discovery. The treatment involves (hemi-)thyroidectomy, possibly followed by additional therapeutic options. After treatment, patients are monitored using serum concentrations of endocrine tumour markers: thyroglobulin (Tg) in case of differentiated cancer and calcitonin in case of medullary thyroid cancer. Measuring Tg and calcitonin concentrations in serum may be challenging. In this review, we provide a complete overview of the evolution in laboratory measurements of Tg and calcitonin, with an emphasis on (pre-)analytical challenges and potential approaches to overcome current pitfalls.

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来源期刊

Journal of Endocrinology 医学-内分泌学与代谢

CiteScore

7.90

自引率

2.50%

发文量

113

审稿时长

4-8 weeks

期刊介绍： Journal of Endocrinology is a leading global journal that publishes original research articles, reviews and science guidelines. Its focus is on endocrine physiology and metabolism, including hormone secretion; hormone action; biological effects. The journal publishes basic and translational studies at the organ, tissue and whole organism level.