紫外线辐射通过β-catenin抑制Dicer的表达。

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Journal of cell science Pub Date : 2024-11-15 Epub Date: 2024-11-26 DOI:10.1242/jcs.261978
Zackie Aktary, Valérie Petit, Irina Berlin, Jeremy Raymond, Frederique Berger, Nisamanee Charoenchon, Evelyne Sage, Juliette Bertrand, Lionel Larue
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引用次数: 0

摘要

紫外线(UV)会促使表皮细胞,尤其是黑色素细胞产生自然反应。人们对暴露于紫外线后黑色素细胞内基因表达和相关信号通路的变化仍不完全清楚。我们的研究结果表明,紫外线照射会抑制 Dicer 的表达。这种抑制与 PI3K、RSK 和 WNT/β-catenin 信号通路的激活密切相关,并与β-catenin 的转录抑制直接相关。值得注意的是,我们在 Dicer 启动子中发现了 LEF/β-catenin 复合物的特定结合位点。总之,这些结果强调了涉及 LEF/β-catenin 的紫外线诱导途径对 Dicer 表达的重要影响。紫外线辐射还降低了已知对黑色素细胞生物学有重要影响的特定 miRNA 的水平。这一通路在管理黑色素细胞生理学方面具有潜在的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
UVB radiation suppresses Dicer expression through β-catenin.

Ultraviolet (UV) rays prompt a natural response in epidermal cells, particularly within melanocytes. The changes in gene expression and related signaling pathways in melanocytes following exposure to UV radiation are still not entirely understood. Our findings reveal that UVB irradiation suppresses the expression of Dicer (also known as Dicer1). This repression is intricately linked to the activation of the phosphoinositide 3-kinase (PI3K), ribosomal S6 kinase (RSK) and Wnt-β-catenin signaling pathways, and is directly associated with transcriptional repression by β-catenin (also known as CTNNB1). Notably, we have identified specific binding sites for the TCF/LEF-β-catenin complex in the Dicer promoter. Collectively, these results emphasize the significance of the UV-induced pathway involving the TCF/LEF-β-catenin complex, which impacts Dicer expression. UV radiation also reduced the levels of specific microRNAs known to be important in the biology of melanocytes. This pathway holds potential importance in governing melanocyte physiology.

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来源期刊
Journal of cell science
Journal of cell science 生物-细胞生物学
CiteScore
7.30
自引率
2.50%
发文量
393
审稿时长
1.4 months
期刊介绍: Journal of Cell Science publishes cutting-edge science, encompassing all aspects of cell biology.
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