妇科癌症患者的激素替代疗法和放射诱发的卵巢早衰。

IF 6.4 1区医学 Q1 ONCOLOGY

International Journal of Radiation Oncology Biology Physics Pub Date : 2024-10-23 DOI:10.1016/j.ijrobp.2024.10.023

Abigail Pepin, Arina Chesnokova, Allyson Pishko, Stefan Gysler, Caitlin Martin, Emily Smith, Megan Kassick, Neil K Taunk

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引用次数: 0

摘要

妇科、胃肠道或泌尿生殖系统恶性肿瘤患者因采用多模式疗法治疗癌症而导致卵巢早衰（POI）的风险较高。卵巢早衰可导致全因死亡率、骨密度、心血管健康、性健康、认知健康和体重的长期下降。事实证明，通过将雌激素浓度恢复到生理水平，HRT 可以扭转这些长期后果。在此，我们将讨论启动 HRT 的实用方法以及需要考虑的挑战。

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Hormone Replacement Therapy in Patients with Gynecologic Cancer and Radiation-Induced Premature Ovarian Insufficiency.

Patients with gynecologic, gastrointestinal, or genitourinary malignancy are at elevated risk of developing premature ovarian insufficiency from the multimodality therapies used to treat their cancers. Premature ovarian insufficiency can result in long-term decrements to all-cause mortality, bone density, cardiovascular health, sexual health, cognitive health, and body mass. Hormone replacement therapy has been demonstrated to reverse these long-term sequalae with the goal of restoring estrogen concentrations to physiological levels. Here, we discuss a practical approach for initiation of hormone replacement therapy as well as challenges to consider.

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来源期刊

International Journal of Radiation Oncology Biology Physics 医学-核医学

CiteScore

11.00

自引率

7.10%

发文量

2538

审稿时长

6.6 weeks

期刊介绍： International Journal of Radiation Oncology • Biology • Physics (IJROBP), known in the field as the Red Journal, publishes original laboratory and clinical investigations related to radiation oncology, radiation biology, medical physics, and both education and health policy as it relates to the field. This journal has a particular interest in original contributions of the following types: prospective clinical trials, outcomes research, and large database interrogation. In addition, it seeks reports of high-impact innovations in single or combined modality treatment, tumor sensitization, normal tissue protection (including both precision avoidance and pharmacologic means), brachytherapy, particle irradiation, and cancer imaging. Technical advances related to dosimetry and conformal radiation treatment planning are of interest, as are basic science studies investigating tumor physiology and the molecular biology underlying cancer and normal tissue radiation response.