与巴塞杜氏病甲状腺功能有关的产后甲状腺眼病诊断率。

IF 1.3 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Nami Suzuki, Jaeduk Yoshimura Noh, Ai Kozaki, Natsuko Watanabe, Ai Yoshihara, Miho Fukushita, Masako Matsumoto, Hideyuki Imai, Shigenori Hiruma, Masahiro Ichikawa, Masakazu Koshibu, Akiko Sankoda, Rei Hirose, Toshu Inoue, Kiminori Sugino, Koichi Ito
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引用次数: 0

摘要

据报道,巴塞杜氏病(Graves' disease,GD)有时会在妊娠期自然好转,但也可能在产后加重或复发由GD引起的甲状腺功能亢进。本研究旨在调查产后甲状腺眼病(TED)的发病率与甲状腺功能障碍的关系。这项回顾性横断面研究收集了2004年1月至2022年8月期间11104例GD患者的分娩病例。在产后12个月内,72名患者(0.65%)被诊断为TED。这72名患者的甲状腺功能包括:9人病情缓解,13人继续服用抗甲状腺药物,50人甲状腺功能障碍;30人新诊断为GD,1人甲状腺功能减退,19人GD复发/复发。在 49 名甲状腺功能障碍患者中,在 TED 诊断和甲状腺功能亢进的发展过程中,促甲状腺激素(TSH)受体抗体(TRAb)和促甲状腺激素受体抗体的中位值没有差异。然而,如果将患者分为新发 GD 组和 GD 复发/复发组,则差异变得显著,新发 GD 患者的 TRAb 水平较高(16.1 对 5.0 IU/L,p < 0.0001;15.0 对 6.0 IU/L,p = 0.0003)。半数以上患者在确诊 TED 之前出现甲状腺功能障碍,每次发生的中位时间分别为 6.5 个月和 8.1 个月。在 72 名患者中,有 8 名患者出现了活动期 TED。在产后新诊断出TED的72例患者中,三分之二伴有甲状腺功能障碍,其中8例处于活动期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Incidence of the postpartum diagnosis of thyroid eye disease in relation to thyroid function in Graves' disease.

It has been reported that Graves' disease (GD) sometimes improves spontaneously during pregnancy, although exacerbation of GD during postpartum period or relapse of hyperthyroidism caused by GD might occur. This study aimed to investigate the incidence of postpartum diagnosis of thyroid eye disease (TED) in relation to thyroid dysfunction. This retrospective cross-sectional study enrolled 11,104 deliveries from the patients with GD between January 2004 and August 2022. Within the 12-month postpartum period, 72 patients (0.65%) were diagnosed with TED. The thyroid function of the 72 patients comprised 9 remission, 13 continued antithyroid medicine, and 50 thyroid dysfunction; 30 newly diagnosed GD, 1 hypothyroidism, and 19 relapse/recurrence of GD. In the 49 patients with thyroid dysfunction, no difference was observed in the median values of thyroid-stimulating hormone (TSH) receptor antibody (TRAb) and TSH receptor stimulating antibody between the TED diagnosis and the development of hyperthyroidism. However, when the patients were classified into the newly developed GD and relapse/recurrence of GD groups, the difference became significant and the TRAb level was high in the newly developed GD (16.1 vs. 5.0 IU/L, p < 0.0001, and 15.0 vs. 6.0 IU/L, p = 0.0003). Thyroid dysfunction preceded TED diagnosis in more than half of the patients and the median time for each event was 6.5 vs. 8.1 months. The active phase TED was observed in 8 of the 72 patients. Of the 72 patients newly diagnosed with TED in postpartum, two-thirds were accompanied by thyroid dysfunction and 8 of them were in active phase.

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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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