带黏膜瓣切口的改良Zenker口周内窥镜肌切开术(Z-POEM)的短期临床和技术效果。

IF 11.5 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Endoscopy Pub Date : 2024-12-18 DOI:10.1055/a-2451-2869
Jose Antonio Almario, Amit Mehta, Apurva Shrigiriwar, Farimah Fayyaz, Mohamed El-Sherbiny, Karim Essam, Hany Haggag, Kerolis Yousef, Abeer A Abdallatef, Shaimaa Elkholy, Andrew Canakis, Raymond E Kim, Dennis Yang, Miguel Puga-Tejada, Juan Alcívar-Vásquez, Maria Egas-Izquierdo, Raquel S Del Valle, Domenica Cunto, Jorge Baquerizo-Burgos, Martha Arevalo-Mora, Carlos Robles-Medranda, Aleksandra Borkowicz, Michał F Kamiński, Michael Lajin, Prashant Kedia, Mouen A Khashab
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引用次数: 0

摘要

背景:Zenker氏憩室(ZD)经口内窥镜肌切开术(Z-POEM)是治疗无症状(ZD)的有效方法。粘膜瓣切口(MFI)是对 Z-POEM 的一种改进。我们对接受 Z-POEM 和 MFI 的患者的技术和临床成功率进行了描述:我们纳入了在 8 个国际中心接受 Z-POEM 和 MFI 治疗的 ZD 患者。主要结果是临床成功率,根据术后 Kothari-Haber 症状评分 (KHSS) 评估,无需再治疗。次要结果包括技术成功率、严重不良事件和需要再治疗的临床复发率:36名患者(69%为男性,年龄69+9岁)接受了Z-POEM和MFI治疗无症状ZD。ZD的平均大小为32毫米(+ 14)。35例(97%)获得临床成功。术前 KHSS 中位数为 6,术后 KHSS 中位数为 1(P 结论:Z-POEM 与 MFI 联合治疗的临床成功率为 97%:采用 MFI 的 Z-POEM 技术和临床成功率都很高。需要进行前瞻性评估,以进一步验证该技术在大 ZD 患者中的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Short-term clinical and technical outcomes of a modified Zenker's peroral endoscopic myotomy with mucosal flap incision.

Zenker's diverticulum peroral endoscopic myotomy (Z-POEM) is an effective treatment for symptomatic Zenker's diverticulum. A modification to Z-POEM involves mucosal flap incision (MFI). We describe the technical and clinical success of patients who underwent Z-POEM with MFI.We included patients who underwent Z-POEM with MFI for Zenker's diverticulum at eight international centers. The primary outcome was the rate of clinical success, assessed by post-procedure Kothari-Haber symptom score (KHSS) without re-treatment. Secondary outcomes included technical success, serious adverse events, and clinical recurrence with need for re-treatment.36 patients (age 69 [SD 9] years; 69% male) underwent Z-POEM with MFI for symptomatic Zenker's diverticulum. Mean diverticulum size was 3.2 (SD 1.4) cm. Clinical success was achieved in 35 patients (97%). Median baseline KHSS was 6 and median post-procedure KHSS was 0 (P < 0.001). Technical success was achieved in all cases. Mean procedure time was 57 (SD 34) minutes and median follow-up time was 196 days (interquartile range 39-499). There was one adverse event (3%), which was treated endoscopically.Z-POEM with MFI had high rates of technical and clinical success. Prospective evaluation is needed to further validate this technique in patients with a large Zenker's diverticulum.

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来源期刊
Endoscopy
Endoscopy 医学-外科
CiteScore
5.80
自引率
11.80%
发文量
1401
审稿时长
2 months
期刊介绍: Endoscopy is a leading journal covering the latest technologies and global advancements in gastrointestinal endoscopy. With guidance from an international editorial board, it delivers high-quality content catering to the needs of endoscopists, surgeons, clinicians, and researchers worldwide. Publishing 12 issues each year, Endoscopy offers top-quality review articles, original contributions, prospective studies, surveys of diagnostic and therapeutic advances, and comprehensive coverage of key national and international meetings. Additionally, articles often include supplementary online video content.
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