circRNAs 在阿尔茨海默氏症病理机制中的作用及作为潜在生物标记物的可能性。

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Neuropharmacology Pub Date : 2024-10-24 DOI:10.2174/011570159X337659241014140824

Zulalai Abuduwaili, Yingao Fan, Wenyuan Tao, Yanting Chen, Yun Xu, Xiaolei Zhu

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引用次数: 0

摘要

阿尔茨海默病（AD）是导致老年痴呆症的最常见的神经退行性疾病，其发病机制尚未完全明确。环状 RNA（circRNA）是通过反向剪接产生的共价封闭 RNA，在阿尔茨海默病的发病机制中具有关键作用。环状RNA参与Aβ和tau的产生和清除，调控神经炎症、突触可塑性以及细胞凋亡和自噬过程，表明环状RNA可能是替代性生物标志物和治疗靶点。我们的综述总结了circRNAs在AD进展和发展中的功能，为circRNAs在AD诊断和治疗中的应用前景提供了启示。

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The Role of circRNAs in the Pathological Mechanisms of Alzheimer's Disease and May Serve as Potential Biomarkers.

Alzheimer's disease (AD) is the most common neurodegenerative disease leading to dementia in the elderly, and the mechanisms of AD have not been fully defined. Circular RNAs (circRNAs), covalently closed RNAs produced by reverse splicing, have critical effects in the pathogenesis of AD. CircRNAs participate in production and clearance of Aβ and tau, regulate neuroinflammation, synaptic plasticity and the process of apoptosis and autophagy, indicating that circRNAs may be alternative biomarkers and therapeutic targets. Our review summarizes the functions of circRNAs in the progression and development of AD, which provide insights into the prospect of circRNAs in the diagnosis and treatment of AD.

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来源期刊

Current Neuropharmacology 医学-神经科学

CiteScore

8.70

自引率

1.90%

发文量

369

审稿时长

>12 weeks

期刊介绍： Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.