{"title":"中国≥65 岁老年人结核分枝杆菌抗原皮试与干扰素-γ 释放测定之间的一致性。","authors":"Yijun He, Lingyu Shen, Jiang Du, Xuefang Cao, Bin Zhang, Dakuan Wang, Boxuan Feng, Zihan Li, Yuanzhi Di, Juanjuan Huang, Tonglei Guo, Jianguo Liang, Jiaoxia Yan, Zisen Liu, Qi Jin, Weitao Duan, Henan Xin, Lei Gao","doi":"10.1016/j.cmi.2024.10.016","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To determine the agreement of Mycobacterium tuberculosis (MTB) antigen-based skin test (TBST) with interferon-gamma release assay (IGRA) in elderly individuals aged ≥ 65 years beyond instruction for use in China.</p><p><strong>Methods: </strong>Based on the baseline survey of randomized controlled trial with objective to explore suitable regimen for tuberculosis (TB) preventive treatment, MTB infection was tested using TBST and IGRA in parallel in rural residents aged 50-70 years by means of a cross-sectional study design.</p><p><strong>Results: </strong>A total of 21219 participants with both TBST and IGRA results were included in this analysis. The concordance between TBST and IGRA was 89.4% (95%CI: 89.0 - 89.8%) with a kappa coefficient of 0.61 (95%CI: 0.60 - 0.62). In those aged ≥ 65 years, the concordance was 86.5% (95%CI: 85.6 - 87.4%) with a kappa coefficient of 0.55 (95%CI: 0.52 - 0.58). 21.2% (35/165) of the participants with indeterminate IGRA results were TBST positive, and 9 of them aged ≥ 65 years.</p><p><strong>Conclusions: </strong>The consistent agreement between TBST and IGRA in individuals aged ≥ 65 years suggests that TBST has potential to be used in the elderly with age beyond instruction for use in China. The respective diagnostic performance of each test will be analyzed when the longitudinal data on incident TB be obtained in the future.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":null,"pages":null},"PeriodicalIF":10.9000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Agreement between Mycobacterium tuberculosis antigen-based skin test and interferon-gamma release assay in elderly individuals aged ≥ 65 years in China.\",\"authors\":\"Yijun He, Lingyu Shen, Jiang Du, Xuefang Cao, Bin Zhang, Dakuan Wang, Boxuan Feng, Zihan Li, Yuanzhi Di, Juanjuan Huang, Tonglei Guo, Jianguo Liang, Jiaoxia Yan, Zisen Liu, Qi Jin, Weitao Duan, Henan Xin, Lei Gao\",\"doi\":\"10.1016/j.cmi.2024.10.016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To determine the agreement of Mycobacterium tuberculosis (MTB) antigen-based skin test (TBST) with interferon-gamma release assay (IGRA) in elderly individuals aged ≥ 65 years beyond instruction for use in China.</p><p><strong>Methods: </strong>Based on the baseline survey of randomized controlled trial with objective to explore suitable regimen for tuberculosis (TB) preventive treatment, MTB infection was tested using TBST and IGRA in parallel in rural residents aged 50-70 years by means of a cross-sectional study design.</p><p><strong>Results: </strong>A total of 21219 participants with both TBST and IGRA results were included in this analysis. The concordance between TBST and IGRA was 89.4% (95%CI: 89.0 - 89.8%) with a kappa coefficient of 0.61 (95%CI: 0.60 - 0.62). In those aged ≥ 65 years, the concordance was 86.5% (95%CI: 85.6 - 87.4%) with a kappa coefficient of 0.55 (95%CI: 0.52 - 0.58). 21.2% (35/165) of the participants with indeterminate IGRA results were TBST positive, and 9 of them aged ≥ 65 years.</p><p><strong>Conclusions: </strong>The consistent agreement between TBST and IGRA in individuals aged ≥ 65 years suggests that TBST has potential to be used in the elderly with age beyond instruction for use in China. The respective diagnostic performance of each test will be analyzed when the longitudinal data on incident TB be obtained in the future.</p>\",\"PeriodicalId\":10444,\"journal\":{\"name\":\"Clinical Microbiology and Infection\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":10.9000,\"publicationDate\":\"2024-10-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Microbiology and Infection\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cmi.2024.10.016\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Microbiology and Infection","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.cmi.2024.10.016","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Agreement between Mycobacterium tuberculosis antigen-based skin test and interferon-gamma release assay in elderly individuals aged ≥ 65 years in China.
Objectives: To determine the agreement of Mycobacterium tuberculosis (MTB) antigen-based skin test (TBST) with interferon-gamma release assay (IGRA) in elderly individuals aged ≥ 65 years beyond instruction for use in China.
Methods: Based on the baseline survey of randomized controlled trial with objective to explore suitable regimen for tuberculosis (TB) preventive treatment, MTB infection was tested using TBST and IGRA in parallel in rural residents aged 50-70 years by means of a cross-sectional study design.
Results: A total of 21219 participants with both TBST and IGRA results were included in this analysis. The concordance between TBST and IGRA was 89.4% (95%CI: 89.0 - 89.8%) with a kappa coefficient of 0.61 (95%CI: 0.60 - 0.62). In those aged ≥ 65 years, the concordance was 86.5% (95%CI: 85.6 - 87.4%) with a kappa coefficient of 0.55 (95%CI: 0.52 - 0.58). 21.2% (35/165) of the participants with indeterminate IGRA results were TBST positive, and 9 of them aged ≥ 65 years.
Conclusions: The consistent agreement between TBST and IGRA in individuals aged ≥ 65 years suggests that TBST has potential to be used in the elderly with age beyond instruction for use in China. The respective diagnostic performance of each test will be analyzed when the longitudinal data on incident TB be obtained in the future.
期刊介绍：
Clinical Microbiology and Infection (CMI) is a monthly journal published by the European Society of Clinical Microbiology and Infectious Diseases. It focuses on peer-reviewed papers covering basic and applied research in microbiology, infectious diseases, virology, parasitology, immunology, and epidemiology as they relate to therapy and diagnostics.
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