沃德三角区骨矿密度水平与腹主动脉钙化之间的关系：来自 2013-2014 年全国健康与营养调查的数据。

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2024-10-24 DOI:10.1016/j.clnesp.2024.10.154

Mengmeng Wang , Degang Mo , Chi Zhou , Mengqi Guo , Wenqiang Zhang , Rui Chen , Jiachao Xu , Ning Zhang , Haichu Yu

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引用次数: 0

摘要

背景与目的：尽管对腹主动脉钙化（AAC）对心血管的影响进行了广泛的研究，但很少有可靠的研究探讨其与沃德氏三角区骨矿物质密度（BMD）的关系。本研究旨在评估全国代表性样本中的这种关系，并比较其与股骨颈 BMD 和总股骨 BMD 的预测价值：我们对 2013-2014 年美国国家健康与营养调查 (NHANES) 数据进行了横断面分析，采用了复杂的分层、多阶段、群组抽样设计。使用 DXA 扫描评估了沃德三角区、股骨颈和全股骨的 BMD 测量值。AAC严重程度由Kauppila评分≥5来定义。通过相关性和线性回归模型确定了 AAC-24 评分的预测因素。应用分层回归和限制性立方样条来探讨亚组和剂量反应关系：在代表美国 1.165625 亿人的 2965 名参与者中，11% 的人患有严重的 AAC。Ward's 三角形 BMD 与 AAC-24 评分呈显著负相关（β = -1.90, 95% CI: -2.80 to -1.00, P < 0.002），并降低了严重 AAC 的风险（OR = 0.85, 95% CI: 0.76 to 0.95, P = 0.010）。Ward's 三角形 BMD 与 AAC 结果之间存在非线性关联。在预测 AAC 方面，Ward's 三角区 BMD 优于股骨颈和全股骨 BMD：结论：较高的沃德三角区 BMD 与较低的严重 AAC 发生几率有关，这表明沃德三角区 BMD 比股骨颈和股骨总 BMD 更有潜力提高 AAC 的早期发现率。医疗服务提供者应考虑沃德氏三角区 BMD 降低对全身动脉粥样硬化的影响，并建议进行早期 AAC 筛查，以加强心血管风险管理。

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Association between Ward's triangle bone mineral density levels and abdominal aortic calcification: Data from the national health and nutrition examination survey 2013–2014

Background & aims

Despite extensive research into the cardiovascular implications of abdominal aortic calcification (AAC), there is a scarcity of robust studies exploring its association with Ward's triangle bone mineral density (BMD). This study aimed to evaluate this relationship in a nationally representative sample and compare the predictive value with femoral neck BMD and total femur BMD.

Methods

We conducted a cross-sectional analysis of 2013–2014 National Health and Nutrition Examination Survey (NHANES) data, utilizing a complex, stratified, multistage, cluster sampling design. BMD measurements at Ward's triangle, femoral neck, and total femur were assessed using DXA scans. AAC severity was defined by a Kauppila score of ≥5. Predictors of AAC-24 scores were identified through correlation and linear regression models. Stratified regression and restricted cubic splines were applied to explore subgroup and dose–response relationships.

Results

Of the 2965 participants representing 116, 562, 500 individuals in the U.S., 11 % had severe AAC. Ward's triangle BMD showed a significant negative association with AAC-24 scores (β = −1.90, 95 % CI: −2.80 to −1.00, P < 0.002) and a reduced risk of severe AAC (OR = 0.85, 95 % CI: 0.76 to 0.95, P = 0.010). Non-linear associations were observed between Ward's triangle BMD and AAC outcomes. Ward's triangle BMD outperformed femoral neck and total femur BMD in predicting AAC.

Conclusions

Higher Ward's triangle BMD is linked to lower odds of severe AAC, highlighting its potential for improved early detection of AAC over femoral neck and total femur BMD. Healthcare providers should consider the implications of reduced Ward's triangle BMD for systemic atherosclerosis and recommend early AAC screening for enhanced cardiovascular risk management.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.