受体 KRAS 基因 rs712 多态性对肝移植后肝细胞癌总生存率的影响

IF 3.2 4区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Tiancheng Chu, Rulin Zhang, Xiaolei Liu, Li Lin, Yanning Li, Ziguang Niu, Heng Quan, Yingying Zhao, Yaohua Li
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引用次数: 0

摘要

肝细胞癌(HCC)复发常见于肝移植(LT)后,严重影响患者的长期生存。以往的研究证明,Rap1A 参与了肝癌的发生和转移,并证明了 KRAS rs712 多态性与 HCC 的显著相关性。然而,KRAS rs712多态性与LT后HCC复发之间的关系仍不清楚。研究分析了2008年3月至2015年12月期间接受LT治疗的93例HCC患者。供体和受体的基因型均被证实为 KRAS rs712。通过单变量和多变量逻辑回归分析,研究了与HCC复发相关的独立风险因素。通过 Cox 回归分析计算了无复发生存期(RFS)和总生存期(OS)。KRAS rs712基因型频率通过Χ2检验确定,KRAS rs712基因型的小等位基因频率(MAFs)通过Hardy-Weinberg平衡法计算。我们发现,受体 KRAS rs712 多态性与 LT 后 HCC 复发显著相关。此外,米兰标准、微血管侵犯和受体KRAS rs712基因型被证实是LT后HCC复发的独立危险因素。供体TG/TT基因型患者的RFS和OS明显高于TT基因型。TNM分期、微血管侵犯、米兰标准、治疗和受体KRAS rs712基因型是影响LT患者RFS的独立因素。受体KRAS rs712多态性与肝移植后HCC复发有关,是肝移植后HCC风险患者总生存率的生物预测因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of recipient KRAS gene rs712 polymorphisms on the overall survival rate of hepatocellular carcinoma after hepatic transplantation.

Hepatocellular carcinoma (HCC) recurrence appears commonly after liver transplantation (LT), and it severely affected the long-term survival of patients. Previous studies have proved that Rap1A is involved in hepatocarcinogenesis and metastasis, and demonstrated the significant association between KRAS rs712 polymorphism and HCC. However, the relationship between KRAS rs712 polymorphism and HCC recurrence after LT remained unclear. A total of 93 HCC patients who underwent LT from March 2008 to Dec 2015 was analyzed. The genotypes of both donors and recipients had been confirmed as KRAS rs712. The independent risk factors that associated with HCC recurrence were investigated with univariate and multivariate logistic regression analysis. The recurrence-free (RFS) and overall survival (OS) were calculated with Cox regression analysis. The KRAS rs712 genotype frequencies were determined using the Χ2 test and the minor allele frequencies (MAFs) of KRAS rs712 genotypes were calculated by Hardy-Weinberg equilibrium. We found that the recipient KRAS rs712 polymorphism was significantly associated with HCC recurrence after LT. Moreover, the Milan criteria, microvascular invasion and recipient KRAS rs712 genotype were proved to be independent risk factors for HCC recurrence after LT. Patients with donor TG/TT genotypes had a significantly higher RFS and OS than TT genotype. The TNM stage, microvascular invasion, Milan criteria, treatment and recipient KRAS rs712 genotype were independent factors for the RFS of LT patients. Recipient KRAS rs712 polymorphism is associated with HCC recurrence after liver transplantation and plays as a promising bio-predictor of overall survival rate of HCC risks after hepatic transplantation.

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来源期刊
Clinical and Experimental Medicine
Clinical and Experimental Medicine 医学-医学:研究与实验
CiteScore
4.80
自引率
2.20%
发文量
159
审稿时长
2.5 months
期刊介绍: Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.
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