牛至水提取物的化学成分、抗氧化能力、急性毒性和抗痛性分析

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2024-10-24 DOI:10.1002/cbdv.202401580

My Ahmed El Amiri, Hamid Kabdy, Abdelfatah Aitbaba, Jawad Laadraoui, Rachida Aboufatima, Loubna El Yazouli, Baslam Abdelmounaim, Soad Moubtakir, Stefania Garzoli, Chait Abderrahman

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引用次数: 0

摘要

植物疗法是将植物提取的化合物用于医疗目的，越来越被认为是现代疗法的重要组成部分。本研究调查了牛至（Origanum majorana L.，AEOM）的水提取物，评估了其植物化学成分、安全性、抗氧化活性和药理作用。通过 LC-MS/MS 分析，确定了多种酚类化合物，其中没食子酸、咖啡酸和绿原酸具有明显的生物活性。定量分析显示，AEOM 含有大量多酚（186.06 ± 0.1 毫克 GAE/克）、类黄酮（72.3 ± 0.9 毫克 QE/克）和缩合单宁（4.49 ± 0.08 毫克 CE/克）。该提取物具有很强的抗氧化活性，在 DPPH 试验中的 IC₅₀值为 2.23 ± 0.03 mg/mL，并表现出相当强的还原力（FRAP 值为 1.9 ± 0.01 mg Fe²⁺/g）。药理评估显示，AEOM 能明显减轻动物模型的疼痛，这表明它具有潜在的镇痛特性。急性毒性研究表明，在剂量高达 800 毫克/千克时，AEOM 不会对肝肾功能或血液参数产生不良影响。镇痛效果可能是由提取物中的类黄酮介导的，它可能会抑制疼痛通路。这些研究结果表明，O. majorana 具有广阔的治疗应用前景，尤其是作为一种天然镇痛剂。

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Analysis of Chemical Composition, Antioxidant Capacity, Acute Toxicity, and Antinociceptive Properties of Aqueous Extract of Origanum Majorana L.

Pharmacological evaluation showed that AEOM significantly reduced pain in an animal model, suggesting potential analgesic properties. Acute toxicity studies indicated no adverse effects on kidney and liver function or blood parameters at doses up to 800 mg/kg. The analgesic effect is likely mediated by flavonoids in the extract, which may inhibit pain pathways. These findings suggest that O. majorana has promising therapeutic applications, particularly as a natural analgesic agent.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.