睡眠呼吸暂停与肌萎缩侧索硬化症：原因、相关性、有无关系？

IF 2.7 3区医学 Q3 NEUROSCIENCES

Brain Sciences Pub Date : 2024-09-27 DOI:10.3390/brainsci14100978

P Hande Ozdinler

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引用次数: 0

摘要

肌萎缩性脊髓侧索硬化症（ALS）是一种进行性神经变性的运动神经元疾病，患者的运动神经元回路的皮质和脊髓部分都会受到影响。神经元选择性易损性的细胞和分子基础已开始显现。然而，目前尚无治疗渐冻人症的有效方法，全世界每年有 20 多万人受到渐冻人症的影响。最近的研究强调了糖皮质系统及其正常功能对清除脑脊液的重要性，而清除脑脊液主要是在睡眠期间进行的。因此，人们推测睡眠问题与神经退行性疾病之间存在潜在联系。本文将讨论目前对这种潜在关联的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sleep Apnea and Amyotrophic Lateral Sclerosis: Cause, Correlation, Any Relation?

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with progressive neurodegeneration, affecting both the cortical and the spinal component of the motor neuron circuitry in patients. The cellular and molecular basis of selective neuronal vulnerability is beginning to emerge. Yet, there are no effective cures for ALS, which affects more than 200,000 people worldwide each year. Recent studies highlight the importance of the glymphatic system and its proper function for the clearance of the cerebral spinal fluid, which is achieved mostly during the sleep period. Therefore, a potential link between problems with sleep and neurodegenerative diseases has been postulated. This paper discusses the present understanding of this potential correlation.

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来源期刊

Brain Sciences Neuroscience-General Neuroscience

CiteScore

4.80

自引率

9.10%

发文量

1472

审稿时长

18.71 days

期刊介绍： Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.