关于非肌层浸润性膀胱癌 (NMIBC) 中半aphorin 4A (sema4A) 和 3C (sema3C) 作用的试验性研究

IF 3.9 3区 工程技术 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Piotr Purpurowicz, Tomasz W Kaminski, Władysław Kordan, Anna Korzekwa, Zbigniew Purpurowicz, Zbigniew Jabłonowski
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引用次数: 0

摘要

背景/目标:膀胱癌是当代泌尿外科中一个非常重要的问题。本试验性研究旨在首次评估非肌层浸润性膀胱癌(NMIBC)患者体内半aphorin 3C (sema3C) 和 4A (sema4A) 的临床实用性。实验方法实验涉及 15 名 NMIBC 患者和 5 名无恶性肿瘤患者作为对照组。使用酶联免疫吸附试验(ELISA)评估血浆和尿液中 sema3C 和 sema4A 的浓度。尿液中的sema4A浓度低于检测水平。结果就血浆中 sema4A 和 sema3C 或尿液中 sema3C 的浓度而言,患者和对照组之间没有明显的统计学差异(P > 0.05)。低级别肿瘤患者血浆中的 sema3C 浓度明显更高(p = 0.0132),Ta 级肿瘤患者血浆中的 sema4A 浓度呈上升趋势。尿液中的 sema3C 浓度与肿瘤大小呈正相关(R = 0.57,p = 0.03)。血浆sema3C浓度与肿瘤分级呈负相关(R = -0.62,p = 0.01)。结论尿液中sema4A的浓度低于检测阈值,不太可能作为NMIBC的标记物。血浆中的 sema4A 浓度以及血浆和尿液中的 sema3C 浓度目前还不能单独用作 NMIBC 的标志物。血浆中的 sema3C 浓度将来有可能被视为低级别肿瘤的标志物。血浆中 sema4A 的浓度将来有可能被视为早期肿瘤的标志物。所有这些观察结果都是初步的,因此必须在更大的群体中进行评估,才能提出可靠的建议。不过,我们的研究为进一步研究开发可用于日常监测和预测癌症病程的潜在检测方法奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Pilot Study of the Role of Semaphorin 4A (sema4A) and 3C (sema3C) in Non-Muscle-Invasive Bladder Cancer (NMIBC).

Background/Objectives: Bladder cancer is a very important issue in contemporary urology. The aim of this pilot study was to assess for the first time the clinical utility of semaphorin 3C (sema3C) and 4A (sema4A) in patients with non-muscle-invasive bladder cancer (NMIBC). Methods: The experiment involved 15 patients with NMIBC and 5 patients without malignancies as the control group. Plasma and urinary concentrations of sema3C and sema4A were assessed by using an enzyme-linked immunosorbent assay (ELISA). Urinary sema4A concentration was below the detection level. Results: There was no statistically significant difference between patients and controls in terms of plasma sema4A and sema3C or urinary sema3C concentrations (p > 0.05). There was a significantly higher sema3C plasma concentration in patients with low-grade tumors (p = 0.0132) and an upward trend in sema4A plasma concentration for the subjects with Ta-stage tumors. Urinary sema3C concentration positively correlated with tumor size (R = 0.57, p = 0.03). Plasma sema3C concentration correlated negatively with tumor grade (R = -0.62, p = 0.01). Conclusions: Urinary sema4A concentration, which is below the detection threshold, is unlikely to be useful as a marker of NMIBC. Plasma sema4A concentration and sema3C concentration in plasma and urine cannot be used as stand-alone markers of NMIBC at this point. The plasma concentration of sema3C can potentially be considered in the future as a marker for tumors of lower grades. Plasma sema4A concentration could potentially be considered in the future as a marker for tumors of earlier stages. All of these observations are preliminary, so they have to be assessed in larger cohorts to make reliable recommendations. Nevertheless, our study lays the groundwork for further research to develop potential tests that could be used in daily practice to monitor and predict the course of cancer.

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来源期刊
Biomedicines
Biomedicines Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.20
自引率
8.50%
发文量
2823
审稿时长
8 weeks
期刊介绍: Biomedicines (ISSN 2227-9059; CODEN: BIOMID) is an international, scientific, open access journal on biomedicines published quarterly online by MDPI.
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