胆固醇水晶球：补充是答案吗？

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2024-10-18 DOI:10.1016/j.kint.2024.08.025

Marina Noris , Giuseppe Remuzzi

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引用次数: 0

摘要

胆固醇结晶栓塞（CCE）是动脉粥样硬化的一种并发症，可导致多个器官的微血管阻塞。由于其后果可能是致命的，而且没有特效治疗方法，因此了解其发病机制并确定治疗策略至关重要。在本期杂志中，Zhao 等人利用肾脏 CCE 小鼠模型证明，抑制 C5a/C5aR 可以预防和解决 CCE 引起的肾血栓形成和血管病变。尽管这些发现必须推广到人体，但它们为治疗 CCE 综合征带来了希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Looking into the cholesterol crystal ball: is complement the answer?

Cholesterol crystal embolism (CCE) is a complication of atherosclerosis and can cause microvascular obstruction in multiple organs. Because the consequences may be fatal, and there is no specific treatment, it is crucial to understand the mechanisms and identify treatment strategies. In this issue, Zhao et al., using a mouse model of kidney CCE, demonstrated that inhibition of C5a/C5aR prevented and resolved CCE-induced renal thrombosis and angiopathy. Although these findings must be extended to human condition, they offer hope for management of CCE syndrome.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.