不要以貌取人:后颈淋巴结唾液腺异位的分泌性癌。

IF 3.2 Q2 PATHOLOGY
Giulia Querzoli, Carlotta Liberale, Vicenzo Maiolo, Daria Maria Filippini, Elisabetta Nobili, Giambattista Siepe, Annalisa Altimari, Gabriele Molteni, Maria Pia Foschini
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引用次数: 0

摘要

异位(Heterotopia)是指胚胎发育过程中在异位部位出现特定的组织,包括在不寻常的位置出现唾液腺组织。异位发生的唾液腺肿瘤非常罕见。分泌性癌(Secretory Carcinoma,SC)是一种罕见的唾液腺癌,其特征是ETV6-NTRK3融合基因,在唾液腺异位中很少见。本文报告了一例起源于颈部淋巴结唾液腺异位的分泌性癌,并对相关文献进行了综述。影像学检查和细针穿刺细胞学检查显示,初步诊断为良性/低度恶性肿瘤。手术(浅表腮腺切除术和肿块切除术)后,组织学检查发现SC位于结内唾液腺异位瘤内,并经分子分析证实。异位唾液腺组织(HSGT)非常罕见,而与肿瘤相关的异位唾液腺组织则更为罕见。异位唾液腺组织上的肿瘤与影响正位唾液腺的肿瘤在组织学上有相似之处。这个独特的病例拓展了人们对 HSGT 上发生 SC 的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Do not Judge a book by its Cover: A Secretory Carcinoma Arising from a Salivary Gland Heterotopia in Laterocervical lymph-node.

Heterotopia, the occurrence of specific tissues in ectopic sites during embryogenesis, includes the presence of salivary gland tissue in unusual locations. Salivary gland neoplasms arising from heterotopic sites are rare. Secretory Carcinoma (SC) is a rare salivary gland carcinoma characterized by ETV6-NTRK3 fusion gene, very rarely described in salivary gland heterotopia. Here a case of SC originating from salivary gland heterotopia in a neck lymph node is reported, together with a literature review.A 66-year-old male presented with a left neck mass. Imaging and fine needle aspiration cytology indicated a preliminary diagnosis of a benign/low-grade malignancy neoplasm.Following surgery (superficial parotidectomy and mass excision), histological examination revealed SC within an intranodal salivary heterotopia, confirmed by molecular analysis.Heterotopic salivary gland tissue (HSGT) is rare, and its association with neoplasms is even rarer. Tumours arising on HSGT, share histological similarities with those affecting orthotopic salivary glands. This unique case expands the understanding of SC occurrences on HSGT.

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来源期刊
CiteScore
5.70
自引率
9.50%
发文量
99
期刊介绍: Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
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