治疗牛皮癣。

The Journal of investigative dermatology Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI:10.1016/j.jid.2024.09.012
Su M Lwin, Shir Azrielant, Juan He, Christopher E M Griffiths
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引用次数: 0

摘要

随着医学的发展,以前被认为是不治之症的疾病也找到了治愈方法,某些类型的癌症就是如此。传统上,"治愈 "一词是指疾病在临床和分子水平上得到缓解,并在停止治疗后继续存在。生物疗法彻底改变了重症银屑病缓解的定义,一些患者的病情得到了长期抑制,但停药后几乎总是复发。我们对银屑病的病理机制有了更深入的了解,再加上细胞疗法后疾病长期痊愈的轶事报道,使我们提出了银屑病是可以治愈的这一假设。我们建议,通过包括生物制剂、先进疗法和生活方式调整在内的早期干预、个性化组合医学方法来恢复免疫平衡,从而治愈银屑病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Curing Psoriasis.

As medicine advances, cures are being found for diseases that were previously considered incurable, as is the case for some types of cancer. Traditionally, the term cure is reserved for resolution of disease, both at a clinical and a molecular level, which continues after cessation of treatment. Biologic therapies have revolutionized the definition of remission in severe psoriasis, with some patients achieving long-lasting disease suppression, but the disease nearly always relapses on withdrawal of the drug. Our improved understanding of the pathomechanisms of psoriasis, coupled with anecdotal reports of long-term clearance of the disease after cell-based therapies, leads us to the hypothesis that psoriasis is curable. We propose that cure of psoriasis can be achieved by restoring immune homeostasis through a combinatorial, personalized medicine approach encompassing early intervention to include biologics, advanced therapeutics, and lifestyle modification.

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