通过光学相干断层血管造影研究旁中心型急性中间黄斑病变的临床特征和灌注密度。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2024-10-18 DOI:10.1016/j.pdpdt.2024.104380

Zhengfeng Liu , Xuemei Pan , Dan Wang , Yingying Zou , Peipei Liu , Ying Wang , Hongsheng Bi , Xiaofeng Xie

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引用次数: 0

摘要

目的：观察旁中央型急性中间黄斑病变（PAMM）的临床特征，并通过光学相干断层血管成像（OCTA）研究PAMM患者浅层毛细血管丛（SCP）和深层毛细血管丛（DCP）灌注密度的变化：方法：共招募了 12 名确诊为 PAMM 的患者（12 只眼）和 13 名健康参与者（13 只眼）。记录了 12 名 PAMM 患者的临床特征。通过 OCTA 测量 PAMM 和健康眼的眼底和眼周（分为颞部、上部、鼻部和下部）的 SCP 和 DCP 灌注密度。此外，还进行了包括 SCP 和 DCP 在内的黄斑地图自动绘制：患者的平均年龄为 48.08 岁（14-72 岁不等）。最佳矫正视力（BCVA）为手指计数（FC）至 1.0。危险因素包括高血压、糖尿病、COVID-19 等。除一名患者患有孤立的 PAMM 外，其他患者均有视网膜血管疾病的迹象。PAMM 眼的光谱域 OCT 图像显示核内层（INL）有高反射。与健康眼相比，PAMM 眼的 SCP 和 DCP 在视网膜旁和视网膜周围的所有区段都明显降低（均 p < 0.05）。PAMM 眼的视网膜旁和视网膜周围的 SCP 平均灌注密度为 46.94±4.34% vs 52.21±3.98% (P=0.002)，健康眼为 44.01±3.95% vs 50.51±3.14 (P=0.000)。PAMM患者眼底和眼周的DCP平均灌注密度分别为51.22±4.16% vs 57.15±3.87% (P=0.002)、47.375±6.23% vs 54.27±5.33% (P=0.002)：结论：PAMM 常伴有并发的眼部和全身疾病。OCTA结果证实，PAMM患者眼底和眼周的SCP和DCP灌注密度明显降低。

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The clinical features and perfusion density in paracentral acute middle maculopathy by optical coherence tomography angiography study

Purpose

To observe the clinical features of the paracentral acute middle maculopathy (PAMM) and to investigate the changes in perfusion density of superficial capillary plexus (SCP) and deep capillary plexus (DCP) in PAMM by optical coherence tomography angiography (OCTA).

Methods

Twelve patients (12 eyes) diagnosed with PAMM and 13 healthy participants (13 eyes) were enrolled. The clinical features of 12 PAMM patients were recorded. The perfusion density of SCP and DCP in the parafovea and perifovea (divided into Temporal, Superior, Nasal, and Inferior) was measured by OCTA in PAMM and healthy eyes. Automated macular maps, including SCP and DCP, were also performed.

Results

The mean age of patients was 48.08 (range 14–72) years. The best corrected visual acuity (BCVA) was from finger count (FC) to 1.0. Risk factors included hypertension, diabetes mellitus, COVID-19, etc. The patients had signs of retinal vascular disease except for one patient with isolated PAMM. A spectral-domain OCT image of the PAMM eye showed hyperreflectivity in the inner nuclear layer (INL). Compared with healthy eyes, SCP and DCP in PAMM eyes were significantly reduced in all sectors (all p < 0.05) in the parafovea and perifovea. The average perfusion density of SCP in parafovea and perifovea in PAMM eyes were 46.94±4.34% vs 52.21±3.98 % (p = 0.002), 44.01±3.95% vs 50.51±3.14 (p = 0.000) in healthy eyes. The average perfusion density of DCP in parafovea and perifovea in PAMM eyes were 51.22±4.16% vs 57.15±3.87 % (p = 0.002), 47.375±6.23% vs 54.27±5.33 % (p = 0.002) in healthy eyes.

Conclusion

PAMM often accompanies concurrent ocular and systemic diseases. OCTA results confirm that the perfusion density of SCP and DCP in the parafovea and perifovea significantly reduced in PAMM patients.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.