有氧运动对血管壁厚度的影响:大鼠模型临床前试验的 Meta 分析。

Fatima Hamza, Syed Nudrat Nawaid Shah, Amna Aamir Khan, Sumaira Imran Farooqui, Kevin Joseph Jerome Borges
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引用次数: 0

摘要

运动会在组织和器官层面促使人体的结构和功能组织发生适应性变化。然而,运动对血管壁形态的影响仍在研究之中。本综述旨在对以前发表的研究数据进行荟萃分析,以确定运动对大型血管壁厚度的影响。在 2022 年 9 月至 2023 年 1 月期间,Ziauddin 康复科学学院使用 Pubmed、CINAHL、Web of Science、Scopus 和 Google Scholar 等数据库和搜索引擎进行了广泛的文献检索,从而完成了这项荟萃分析。根据平均差异估计值对研究进行评估,并使用随机效应模型计算汇集效应大小。此外,还使用 SYRCLE 的偏倚风险工具和 CAMARADES 计算了偏倚风险。荟萃分析共纳入了五项符合条件的临床前试验,这些试验使用大鼠模型并提供了相关数据,以确定运动对血管壁厚度的影响。结果显示,有氧运动能显著降低血管壁厚度(SMD -0.854 5%; CI: -1.365 to -0.344; p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Aerobic Exercise on Vascular Wall Thickness: A Meta-Analysis of Pre-Clinical Trials on Rat Model.

Exercise instigates adaptations in structural as well as functional organisation of the body at tissue and organ levels. However, the effect of exercise on vascular wall morphology is still under investigation. The objective of the review is to provide a meta-analysis of data from the previously published research to provide compiled analysis to determine the effect of exercise on the thickness of large-sized vessel walls. This meta-analysis was executed at the Ziauddin College of Rehabilitation Sciences with an extensive literature search using databases and search engines such as Pubmed, CINAHL, Web of Science, Scopus, and Google Scholar between September 2022 and January 2023. Studies were appraised according to an estimate of mean difference and pooled effect size was calculated using a random effect model. The risk of bias was also calculated using SYRCLE's risk of bias tool and CAMARADES. Overall, five eligible pre-clinical trials using rat models with pertinent data to determine the effect of exercise on vessel wall thickness were included in the meta-analysis. The results showed that aerobic exercise significantly reduced the vessel wall thickness (SMD -0.854 5%; CI: -1.365 to -0.344; p <0.001). Moreover, no significant publication bias was found through funnel plot and statistical test (Egger's p = 0.276; Begg's p = 0.624). However, an extensive review of the literature currently available on the topic has shown mixed findings that are consistent with the study and vice versa. Therefore, it indicated the need for sub-group analysis with different types of exercises for more peculiar clinical approaches. Key Words: Morphometry, Animal studies meta-analysis, Media thickness, Physical activity, Vascular morphology.

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