Julia Penna de Andrade, Camilla Faria Soares, André Luiz de Moura Junqueira, Daniel Reis Santos, Marcelo Pires Nogueira de Carvalho, Karen Yumi Ribeiro Nakagaki, Érica Almeida Viscone, Lize Borges, Geovanni Dantas Cassali, Rodrigo Dos Santos Horta
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引用次数: 0
摘要
一只 8 岁的雄兔（Oryctolagus cuniculus）在第四根指头和附属指头的近端区域出现一个皮下肿块，大小为 5.5 x 3.5 x 5.2 厘米。肿块无秃发，表面不规则，有溃疡和坏死，主要呈淡褐色和浅褐色。影像学检查显示，骨骼和邻近的骨膜没有受累。肿块被小幅切除，并在手术床上进行了电化学疗法（ECT）。组织病理学和免疫组化分析显示，Vimentin、Runx-2 和 ki-67 呈阳性反应，诊断为骨外骨肉瘤（ESOS）。本报告描述了一例兔 ESOS 病例，从而描述了其临床表现、解剖病理特征、诊断方法和建议的治疗干预措施。
Histopathological and immunohistochemical analysis of a suspected extraskeletal osteosarcoma in a rabbit (Oryctolagus cuniculus).
An 8-year-old male rabbit (Oryctolagus cuniculus) presented with a subcutaneous mass in the proximal region of the fourth and accessory digit measuring 5.5 x 3.5 x 5.2cm. The mass was non-alopecic and exhibited irregular surface, ulceration and necrosis with predominantly pale and light brown coloring. Radiography revealed no involvement of bone and adjacent periosteum. The mass was marginally resected and the electrochemotherapy (ECT) was performed on the surgical bed. Histopathology and immunohistochemical analysis revealed positive reactions for Vimentin, Runx-2 and ki-67, leading to a diagnosis of extraskeletal osteosarcoma (ESOS). This report described a case of ESOS in a rabbit, thereby delineating its clinical presentation, anatomopathological characteristics, diagnostic modalities and recommended therapeutic interventions.
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