从转录组学揭示衰老。

IF 13.6 2区 生物学 Q1 GENETICS & HEREDITY
Yuanfang Huang, Shouxuan Zhu, Shuai Yao, Haotian Zhai, Chenyang Liu, Jing-Dong J Han
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引用次数: 0

摘要

衰老研究是一项至关重要的工作,旨在阐明衰老和老年相关疾病的潜在生物机制,并促进健康长寿。最近在转录组学技术方面取得的进展,如大容量 RNA 测序(RNA-seq)、单细胞转录组学和空间转录组学,彻底改变了我们以前所未有的分辨率和规模研究衰老的能力。这些技术为发现生物标志物、阐明分子通路以及开发针对老年相关疾病的靶向治疗策略提供了新的机遇。这篇综述探讨了不同类型转录本(如 mRNA、长非编码(lnc)RNA、tRNA 和 miRNA)在衰老方面的最新突破,重点介绍了主要发现,并讨论了它们对该领域未来研究的潜在影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unraveling aging from transcriptomics.

Research into aging constitutes a pivotal endeavor aimed at elucidating the underlying biological mechanisms governing aging and age-associated diseases, as well as promoting healthy longevity. Recent advances in transcriptomic technologies, such as bulk RNA sequencing (RNA-seq), single-cell transcriptomics, and spatial transcriptomics, have revolutionized our ability to study aging at unprecedented resolution and scale. These technologies present novel opportunities for the discovery of biomarkers, elucidation of molecular pathways, and development of targeted therapeutic strategies for age-related disorders. This review surveys recent breakthroughs in different types of transcripts on aging, such as mRNA, long noncoding (lnc)RNA, tRNA, and miRNA, highlighting key findings and discussing their potential implications for future studies in this field.

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来源期刊
Trends in Genetics
Trends in Genetics 生物-遗传学
CiteScore
20.90
自引率
0.90%
发文量
160
审稿时长
6-12 weeks
期刊介绍: Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.
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