2011 至 2020 年间妊娠头三个月使用喹诺酮类药物与后代患特应性皮炎、哮喘和过敏症的风险。

IF 2.8 Q2 INFECTIOUS DISEASES
Jungmi Chae, Yeon-Mi Choi, Yong Chan Kim, Dong-Sook Kim
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引用次数: 0

摘要

背景:许多孕妇因感染而接受抗生素治疗。我们调查了韩国孕妇在怀孕头三个月使用喹诺酮类药物与婴儿不良健康后果风险之间的关系:这项以人口为基础的全国性队列研究使用了国民健康保险索赔数据库中的母婴对数据。研究队列包括 2011 年 1 月 1 日至 2020 年 12 月 31 日期间的 2,177,765 例妊娠,其中 87,456 名妇女在妊娠期间服用了喹诺酮类药物。经过倾向得分匹配后,喹诺酮类药物使用者和非抗生素使用者的最终研究对象人数均为 84,365 人。我们研究了受试者接触喹诺酮类抗生素的情况。主要结果指标是特应性皮炎、哮喘和过敏的绝对风险和相对风险。我们对潜在的混杂因素进行了调整:4.01%的孕妇在怀孕头三个月至少服用过一次喹诺酮类药物。喹诺酮类药物使用者患特应性皮炎、哮喘和过敏症的绝对风险明显高于非抗生素使用者,这些疾病的风险比(RRs)明显升高(特应性皮炎:RR,1.09;95% 置信区间 [CI],1.08-1.11,哮喘:RR,1.04;95% 置信区间 [CI],1.03-1.05,过敏:结论:我们发现,怀孕头三个月接触喹诺酮类药物会增加患特应性皮炎、哮喘和过敏的风险。这项研究可为医生在为孕妇选择抗生素时提供有用的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Quinolone Use during the First Trimester of Pregnancy and the Risk of Atopic Dermatitis, Asthma, and Allergies of Offspring during 2011 to 2020.

Background: Many pregnant women receive antibiotic treatment for infections. We investigated the association between quinolone use in the first trimester of pregnancy and the risk of adverse health outcomes for the child in Korea.

Materials and methods: This nationwide, population-based cohort study used data on mother-child pairs from the National Health Insurance claims database. This study cohort included 2,177,765 pregnancies from January 1, 2011, to December 31, 2020, and 87,456 women were prescribed quinolones during pregnancy. After propensity score matching, the final number of study subjects was 84,365 for both quinolone and non-antibiotic users. We examined the subjects' exposure to quinolone antibiotics. The main outcome measures were absolute and relative risks of atopic dermatitis, asthma, and allergies. We adjusted for potential confounders.

Results: Quinolones were prescribed at least once during the first trimester in 4.01% of pregnancies. Quinolone users had significantly higher absolute risks than non-antibiotic users for atopic dermatitis, asthma, and allergies, with significantly elevated risk ratios (RRs) for these conditions (atopic dermatitis: RR, 1.09; 95% confidence interval [CI], 1.08-1.11, asthma: RR, 1.04; 95% CI, 1.03-1.05, and allergies: RR, 1.10; 95% CI, 1.08-1.13).

Conclusions: We found that quinolone exposure during the first trimester of pregnancy increased the risk of atopic dermatitis, asthma, and allergies. This study could provide physicians with useful information when selecting antibiotics for pregnant women.

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来源期刊
Infection and Chemotherapy
Infection and Chemotherapy INFECTIOUS DISEASES-
CiteScore
6.60
自引率
11.90%
发文量
71
审稿时长
22 weeks
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