含拍蛋白样磷脂酶域的 3 基因在降低新诊断糖尿病患者肾功能中的作用

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-10-01 DOI:10.1016/j.dsx.2024.103137

Oana Patricia Zaharia , Klaus Strassburger , Birgit Knebel , Christian Binsch , Yuliya Kupriyanova , Clara Möser , Kálmán Bódis , Katsiaryna Prystupa , Iryna Yurchenko , Dania Marel Mendez Cardenas , Martin Schön , Christian Herder , Hadi Al-Hasani , Vera Schrauwen-Hinderling , Karin Jandeleit-Dahm , Robert Wagner , Michael Roden , GDS Group

{"title":"含拍蛋白样磷脂酶域的 3 基因在降低新诊断糖尿病患者肾功能中的作用","authors":"Oana Patricia Zaharia , Klaus Strassburger , Birgit Knebel , Christian Binsch , Yuliya Kupriyanova , Clara Möser , Kálmán Bódis , Katsiaryna Prystupa , Iryna Yurchenko , Dania Marel Mendez Cardenas , Martin Schön , Christian Herder , Hadi Al-Hasani , Vera Schrauwen-Hinderling , Karin Jandeleit-Dahm , Robert Wagner , Michael Roden , GDS Group","doi":"10.1016/j.dsx.2024.103137","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><div>We examined the association of the G allele in the single-nucleotide polymorphism (SNP) rs738409 in the third exon of patatin-like phospholipase domain-containing 3 gene (<em>PNPLA3)</em> gene, with chronic kidney disease in diabetes endotypes.</div></div><div><h3>Methods</h3><div>Participants with recent-onset diabetes (n = 707) from the prospective German Diabetes Study (GDS) underwent cluster assignment, detailed phenotyping, genotyping and magnetic resonance spectroscopy to quantify hepatocellular lipid content (HCL).</div></div><div><h3>Results</h3><div>Severe insulin-resistant diabetes (SIRD) had the lowest glomerular filtration rates (eGFR) and highest HCL compared to severe insulin-deficient, moderate obesity-related, moderate age-related and severe autoimmune diabetes endotypes (all p < 0.05). HCL was negatively associated with eGFR (r = −0.287, p < 0.01) across all groups. Stratification by G-allele carrier status did not reveal any association between HCL and eGFR among the endotypes. However, the proportion of G-allele carriers increased from 44 % for eGFR >60 ml/min to 52 % for eGFR <60 ml/min (p < 0.05).</div></div><div><h3>Conclusions</h3><div>The <em>PNPLA3</em> polymorphism may contribute to declining kidney function independently of liver lipids.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 10","pages":"Article 103137"},"PeriodicalIF":4.3000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus\",\"authors\":\"Oana Patricia Zaharia , Klaus Strassburger , Birgit Knebel , Christian Binsch , Yuliya Kupriyanova , Clara Möser , Kálmán Bódis , Katsiaryna Prystupa , Iryna Yurchenko , Dania Marel Mendez Cardenas , Martin Schön , Christian Herder , Hadi Al-Hasani , Vera Schrauwen-Hinderling , Karin Jandeleit-Dahm , Robert Wagner , Michael Roden , GDS Group\",\"doi\":\"10.1016/j.dsx.2024.103137\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aims</h3><div>We examined the association of the G allele in the single-nucleotide polymorphism (SNP) rs738409 in the third exon of patatin-like phospholipase domain-containing 3 gene (<em>PNPLA3)</em> gene, with chronic kidney disease in diabetes endotypes.</div></div><div><h3>Methods</h3><div>Participants with recent-onset diabetes (n = 707) from the prospective German Diabetes Study (GDS) underwent cluster assignment, detailed phenotyping, genotyping and magnetic resonance spectroscopy to quantify hepatocellular lipid content (HCL).</div></div><div><h3>Results</h3><div>Severe insulin-resistant diabetes (SIRD) had the lowest glomerular filtration rates (eGFR) and highest HCL compared to severe insulin-deficient, moderate obesity-related, moderate age-related and severe autoimmune diabetes endotypes (all p < 0.05). HCL was negatively associated with eGFR (r = −0.287, p < 0.01) across all groups. Stratification by G-allele carrier status did not reveal any association between HCL and eGFR among the endotypes. However, the proportion of G-allele carriers increased from 44 % for eGFR >60 ml/min to 52 % for eGFR <60 ml/min (p < 0.05).</div></div><div><h3>Conclusions</h3><div>The <em>PNPLA3</em> polymorphism may contribute to declining kidney function independently of liver lipids.</div></div>\",\"PeriodicalId\":48252,\"journal\":{\"name\":\"Diabetes & Metabolic Syndrome-Clinical Research & Reviews\",\"volume\":\"18 10\",\"pages\":\"Article 103137\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diabetes & Metabolic Syndrome-Clinical Research & Reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S187140212400198X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S187140212400198X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

摘要

目的：我们研究了单核苷酸多态性（SNP）rs738409中的G等位基因与糖尿病内型中慢性肾脏疾病的关系：方法：对前瞻性德国糖尿病研究（GDS）中新近发病的糖尿病患者（n = 707）进行分组、详细表型分析、基因分型和磁共振波谱分析，以量化肝细胞脂质含量（HCL）：结果：与重度胰岛素缺乏、中度肥胖相关、中度年龄相关和重度自身免疫性糖尿病内型相比，重度胰岛素抵抗性糖尿病（SIRD）的肾小球滤过率（eGFR）最低，HCL最高（eGFR结论均为60毫升/分钟至52%）：PNPLA3多态性可能会导致肾功能下降，而与肝脏血脂无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus

Aims

We examined the association of the G allele in the single-nucleotide polymorphism (SNP) rs738409 in the third exon of patatin-like phospholipase domain-containing 3 gene (PNPLA3) gene, with chronic kidney disease in diabetes endotypes.

Methods

Participants with recent-onset diabetes (n = 707) from the prospective German Diabetes Study (GDS) underwent cluster assignment, detailed phenotyping, genotyping and magnetic resonance spectroscopy to quantify hepatocellular lipid content (HCL).

Results

Severe insulin-resistant diabetes (SIRD) had the lowest glomerular filtration rates (eGFR) and highest HCL compared to severe insulin-deficient, moderate obesity-related, moderate age-related and severe autoimmune diabetes endotypes (all p < 0.05). HCL was negatively associated with eGFR (r = −0.287, p < 0.01) across all groups. Stratification by G-allele carrier status did not reveal any association between HCL and eGFR among the endotypes. However, the proportion of G-allele carriers increased from 44 % for eGFR >60 ml/min to 52 % for eGFR <60 ml/min (p < 0.05).

Conclusions

The PNPLA3 polymorphism may contribute to declining kidney function independently of liver lipids.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Diabetes & Metabolic Syndrome-Clinical Research & Reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

22.90

自引率

2.00%

发文量

248

审稿时长

51 days

期刊介绍： Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.