溃疡性结肠炎与急性阑尾炎之间的关系--孟德尔随机研究。

IF 2.7 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Revista Espanola De Enfermedades Digestivas Pub Date : 2024-10-18 DOI:10.17235/reed.2024.10818/2024

Sangsang Chen, Zhebin Dong, Hanting Xiang, Chao Liang

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引用次数: 0

摘要

虽然 UC 的病因尚不明确，但一些研究表明阑尾可能是 UC 的起始点，而且 UC 患者中阑尾炎的发病率很高。我们进行了磁共振分析，以研究 UC 与急性阑尾炎之间是否存在潜在的因果关系。我们的磁共振研究显示，UC 的遗传责任（OR, 0.9362; 95% CI 0.9014 - 0.9723; p = 0.00064）与急性阑尾炎风险的降低有关。未来还需要更多的研究来支持我们的发现，并更好地解释为什么 UC 可降低急性阑尾炎的风险。

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Association between ulcerative colitis and acute appendicitis - A Mendelian randomization study.

Although the etiology of UC is not clear, some studies show that the appendix may be the starting point of UC, and the incidence of appendicitis is high in patients with UC. We performed a MR analysis to examine whether there is a potential causal relationship between UC and acute appendicitis. Our MR study revealed that the genetic liability of UC (OR, 0.9362; 95% CI 0.9014 - 0.9723; p = 0.00064) was associated with a decreased risk of acute appendicitis. More research is needed in the future to support our findings and better explain why UC reduces the risk of acute appendicitis.

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来源期刊

Revista Espanola De Enfermedades Digestivas 医学-胃肠肝病学

CiteScore

2.00

自引率

25.00%

发文量

400

审稿时长

6-12 weeks

期刊介绍： La Revista Española de Enfermedades Digestivas, Órgano Oficial de la Sociedad Española de Patología Digestiva (SEPD), Sociedad Española de Endoscopia Digestiva (SEED) y Asociación Española de Ecografía Digestiva (AEED), publica artículos originales, editoriales, revisiones, casos clínicos, cartas al director, imágenes en patología digestiva, y otros artículos especiales sobre todos los aspectos relativos a las enfermedades digestivas.