坚持低脂饮食模式可降低头颈癌风险：来自 PLCO 试验的证据。

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2024-10-17 DOI:10.1186/s12937-024-01026-z

Rong Wang, Haoyun Luo, Yijing Ye, Ling Xiang, Qijiu Chen

{"title":"坚持低脂饮食模式可降低头颈癌风险：来自 PLCO 试验的证据。","authors":"Rong Wang, Haoyun Luo, Yijing Ye, Ling Xiang, Qijiu Chen","doi":"10.1186/s12937-024-01026-z","DOIUrl":null,"url":null,"abstract":"Purpose: Low-fat dietary (LFD) pattern refers to a dietary structure with reduced fat intake. The aim was to investigate the association between LFD pattern and risk of head and neck cancer (HNC).Methods: Data were derived from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. LFD score was used to assess adherence to an LFD pattern, with higher scores indicating greater adherence. Cox regression was used to evaluate the association between LFD score and risk of HNC and its subtypes. To visualize the trend in risk of HNC and its subtypes with changing LFD score, restricted cubic spline plots were utilized. A series of subgroup analyses were conducted to identify potential confounders. Sensitivity analyses were performed to assess the robustness of the results.Results: Among 98,459 participants of PLCO trial, 268 cases with HNC were identified during an average of 8.8 years of follow-up. In the fully adjusted model, participants in the highest compared with the lowest quartiles of LFD score had a lower risk of HNC (HR Q4 vs. Q1: 0.60; 95% CI: 0.40-0.90; P for trend = 0.026) and larynx cancer (HRQ4 vs. Q1: 0.46; 95% CI: 0.22-0.96; P for trend = 0.039). The restricted cubic spline plots demonstrated a linear dose-response relationship between the LFD score and the risk of HNC and its subtypes (all P for nonlinearity > 0.05). The primary association remained robust in the sensitivity analysis.Conclusion: Our findings suggest that adherence to an LFD pattern may lower the risk of HNC in the US population.","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"23 1","pages":"125"},"PeriodicalIF":4.4000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484361/pdf/","citationCount":"0","resultStr":"{\"title\":\"Adherence to a low-fat dietary pattern reduces head and neck cancer risk: evidence from the PLCO trial.\",\"authors\":\"Rong Wang, Haoyun Luo, Yijing Ye, Ling Xiang, Qijiu Chen\",\"doi\":\"10.1186/s12937-024-01026-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Purpose: Low-fat dietary (LFD) pattern refers to a dietary structure with reduced fat intake. The aim was to investigate the association between LFD pattern and risk of head and neck cancer (HNC).Methods: Data were derived from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. LFD score was used to assess adherence to an LFD pattern, with higher scores indicating greater adherence. Cox regression was used to evaluate the association between LFD score and risk of HNC and its subtypes. To visualize the trend in risk of HNC and its subtypes with changing LFD score, restricted cubic spline plots were utilized. A series of subgroup analyses were conducted to identify potential confounders. Sensitivity analyses were performed to assess the robustness of the results.Results: Among 98,459 participants of PLCO trial, 268 cases with HNC were identified during an average of 8.8 years of follow-up. In the fully adjusted model, participants in the highest compared with the lowest quartiles of LFD score had a lower risk of HNC (HR Q4 vs. Q1: 0.60; 95% CI: 0.40-0.90; P for trend = 0.026) and larynx cancer (HRQ4 vs. Q1: 0.46; 95% CI: 0.22-0.96; P for trend = 0.039). The restricted cubic spline plots demonstrated a linear dose-response relationship between the LFD score and the risk of HNC and its subtypes (all P for nonlinearity > 0.05). The primary association remained robust in the sensitivity analysis.Conclusion: Our findings suggest that adherence to an LFD pattern may lower the risk of HNC in the US population.\",\"PeriodicalId\":19203,\"journal\":{\"name\":\"Nutrition Journal\",\"volume\":\"23 1\",\"pages\":\"125\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484361/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12937-024-01026-z\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12937-024-01026-z","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

摘要

目的：低脂膳食（LFD）模式是指减少脂肪摄入的膳食结构。目的是研究低脂饮食模式与头颈癌（HNC）风险之间的关系：数据来自前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验（PLCO）。LFD评分用于评估LFD模式的依从性，分数越高表示依从性越高。采用 Cox 回归评估 LFD 评分与 HNC 及其亚型风险之间的关系。为直观显示HNC及其亚型的风险随LFD评分变化的趋势，采用了限制性立方样条图。进行了一系列亚组分析，以确定潜在的混杂因素。为评估结果的稳健性，还进行了敏感性分析：在PLCO试验的98459名参与者中，平均8.8年的随访中发现了268例HNC病例。在完全调整模型中，与LFD得分最低的四分位数相比，LFD得分最高的参与者罹患HNC（HR Q4 vs. Q1：0.60；95% CI：0.40-0.90；P=0.026）和喉癌（HRQ4 vs. Q1：0.46；95% CI：0.22-0.96；P=0.039）的风险较低。限制性三次样条图显示，LFD评分与HNC及其亚型的风险之间存在线性剂量-反应关系（所有非线性P均大于0.05）。在敏感性分析中，主要的关联性仍然很强：我们的研究结果表明，坚持 LFD 模式可降低美国人群罹患 HNC 的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Adherence to a low-fat dietary pattern reduces head and neck cancer risk: evidence from the PLCO trial.

Purpose: Low-fat dietary (LFD) pattern refers to a dietary structure with reduced fat intake. The aim was to investigate the association between LFD pattern and risk of head and neck cancer (HNC).

Methods: Data were derived from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. LFD score was used to assess adherence to an LFD pattern, with higher scores indicating greater adherence. Cox regression was used to evaluate the association between LFD score and risk of HNC and its subtypes. To visualize the trend in risk of HNC and its subtypes with changing LFD score, restricted cubic spline plots were utilized. A series of subgroup analyses were conducted to identify potential confounders. Sensitivity analyses were performed to assess the robustness of the results.

Results: Among 98,459 participants of PLCO trial, 268 cases with HNC were identified during an average of 8.8 years of follow-up. In the fully adjusted model, participants in the highest compared with the lowest quartiles of LFD score had a lower risk of HNC (HR _{Q4 vs. Q1}: 0.60; 95% CI: 0.40-0.90; P for trend = 0.026) and larynx cancer (HR_{Q4 vs. Q1}: 0.46; 95% CI: 0.22-0.96; P for trend = 0.039). The restricted cubic spline plots demonstrated a linear dose-response relationship between the LFD score and the risk of HNC and its subtypes (all P for nonlinearity > 0.05). The primary association remained robust in the sensitivity analysis.

Conclusion: Our findings suggest that adherence to an LFD pattern may lower the risk of HNC in the US population.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.