大脑中的先天性淋巴细胞：聚焦缺血性中风。

IF 2.9 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Microvascular research Pub Date : 2024-10-18 DOI:10.1016/j.mvr.2024.104755

Khiany Mathias , Richard Simon Machado , Taise Cardoso , Anita dal Bó Tiscoski , Amanda Christine da Silva Kursancew , Josiane Somariva Prophiro , Jaqueline Generoso , Fabricia Petronilho

{"title":"大脑中的先天性淋巴细胞：聚焦缺血性中风。","authors":"Khiany Mathias , Richard Simon Machado , Taise Cardoso , Anita dal Bó Tiscoski , Amanda Christine da Silva Kursancew , Josiane Somariva Prophiro , Jaqueline Generoso , Fabricia Petronilho","doi":"10.1016/j.mvr.2024.104755","DOIUrl":null,"url":null,"abstract":"<div><div>The innate immune system consists of a diverse set of immune cells, including innate lymphoid cells (ILCs), which are grouped into subsets based on their transcription factors and cytokine profiles. Among these are natural killer (NK) cells, group 1 ILCs, group 2 ILCs, group 3 ILCs, and lymphoid tissue inducers (LTi). Unlike T and B cells, ILCs do not express the diverse antigen receptors typically found on those cells. Although ILCs function in various systems, further research is needed to understand their role in the brain and their involvement in neurological diseases such as stroke. This review explores the general immunological aspects of ILCs, with a particular focus on their role in the central nervous system and the pathophysiology of ischemic stroke.</div></div>","PeriodicalId":18534,"journal":{"name":"Microvascular research","volume":"157 ","pages":"Article 104755"},"PeriodicalIF":2.9000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Innate lymphoid cells in the brain: Focus on ischemic stroke\",\"authors\":\"Khiany Mathias , Richard Simon Machado , Taise Cardoso , Anita dal Bó Tiscoski , Amanda Christine da Silva Kursancew , Josiane Somariva Prophiro , Jaqueline Generoso , Fabricia Petronilho\",\"doi\":\"10.1016/j.mvr.2024.104755\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The innate immune system consists of a diverse set of immune cells, including innate lymphoid cells (ILCs), which are grouped into subsets based on their transcription factors and cytokine profiles. Among these are natural killer (NK) cells, group 1 ILCs, group 2 ILCs, group 3 ILCs, and lymphoid tissue inducers (LTi). Unlike T and B cells, ILCs do not express the diverse antigen receptors typically found on those cells. Although ILCs function in various systems, further research is needed to understand their role in the brain and their involvement in neurological diseases such as stroke. This review explores the general immunological aspects of ILCs, with a particular focus on their role in the central nervous system and the pathophysiology of ischemic stroke.</div></div>\",\"PeriodicalId\":18534,\"journal\":{\"name\":\"Microvascular research\",\"volume\":\"157 \",\"pages\":\"Article 104755\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-10-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microvascular research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0026286224001043\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microvascular research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0026286224001043","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

摘要

先天性免疫系统由多种免疫细胞组成，包括先天性淋巴细胞（ILCs），这些细胞根据其转录因子和细胞因子特征被分为不同的亚群。其中包括自然杀伤（NK）细胞、第 1 组 ILC、第 2 组 ILC、第 3 组 ILC 和淋巴组织诱导体（LTi）。与 T 细胞和 B 细胞不同，ILCs 不表达这些细胞上常见的多种抗原受体。虽然 ILCs 在多个系统中发挥作用，但要了解它们在大脑中的作用以及与中风等神经系统疾病的关系，还需要进一步的研究。本综述探讨了 ILCs 的一般免疫学方面，尤其侧重于它们在中枢神经系统中的作用以及缺血性中风的病理生理学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Innate lymphoid cells in the brain: Focus on ischemic stroke

The innate immune system consists of a diverse set of immune cells, including innate lymphoid cells (ILCs), which are grouped into subsets based on their transcription factors and cytokine profiles. Among these are natural killer (NK) cells, group 1 ILCs, group 2 ILCs, group 3 ILCs, and lymphoid tissue inducers (LTi). Unlike T and B cells, ILCs do not express the diverse antigen receptors typically found on those cells. Although ILCs function in various systems, further research is needed to understand their role in the brain and their involvement in neurological diseases such as stroke. This review explores the general immunological aspects of ILCs, with a particular focus on their role in the central nervous system and the pathophysiology of ischemic stroke.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Microvascular research 医学-外周血管病

CiteScore

6.00

自引率

3.20%

发文量

158

审稿时长

43 days

期刊介绍： Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured. Research Areas include: • Angiogenesis • Biochemistry • Bioengineering • Biomathematics • Biophysics • Cancer • Circulatory homeostasis • Comparative physiology • Drug delivery • Neuropharmacology • Microvascular pathology • Rheology • Tissue Engineering.