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引用次数: 0
摘要
过去几十年来，成人急性淋巴细胞白血病（ALL）患者的预后有所改善。这归功于多种因素的综合作用，包括对急性淋巴细胞白血病亚型的更精确识别、预后因素评估的完善、儿科化疗方案的改进，特别是新型靶向和免疫疗法以及工程细胞疗法等的应用。这些疗法最初是为复发或难治患者开发的，但现在已被纳入一线治疗，代表着 ALL 治疗向前迈出了一大步。本综述重点介绍 ALL 特征描述的最新进展，尤其是成人 ALL 的治疗。
Novel prognostic factors and therapeutic advances in adult acute lymphoblastic leukemia.
The prognosis of adult patients with acute lymphoblastic leukemia (ALL) has improved in the last decades. This has been due to the sum of several factors including more precise recognition of the ALL subtypes, refinement of the assessment of prognostic factors, improvement in pediatric-inspired chemotherapy regimens and especially to the incorporation of novel targeted and immune therapeutics, as well as engineered cellular therapies, among others. These therapies were initially developed for relapsed or refractory patients but are now being incorporated into frontline treatment and represent a major step forward in ALL therapy. This review focuses on the recent advances in ALL characterization and especially on the treatment of ALL in adults.
期刊介绍：
Leukemia & Lymphoma in its fourth decade continues to provide an international forum for publication of high quality clinical, translational, and basic science research, and original observations relating to all aspects of hematological malignancies. The scope ranges from clinical and clinico-pathological investigations to fundamental research in disease biology, mechanisms of action of novel agents, development of combination chemotherapy, pharmacology and pharmacogenomics as well as ethics and epidemiology. Submissions of unique clinical observations or confirmatory studies are considered and published as Letters to the Editor
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