重度抑郁障碍患者思维与行动融合的神经相关性及其与反刍的关联。

IF 3.7 2区 医学 Q1 PSYCHIATRY
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引用次数: 0

摘要

思想-行动融合(TAF)是一种元认知信念,即思想的力量会产生现实生活中的后果,往往会诱发不愉快的内心体验,并招致反刍等应对策略。因此,本研究旨在探讨TAF的神经相关性及其与抑郁症反刍的关联。共有37名重度抑郁障碍(MDD)患者和37名健康对照组(HCs)接受了功能磁共振成像的TAF诱导任务和心理评估。在TAF诱导任务中,参与者被要求读出一个亲密的人(CP)或中立的人(NP)的名字,并与消极(Neg)TAF和中立(Neu)对照语句相关联。在这项研究中,我们的TAF诱导任务激活了MDD组和HC组的脑区,包括突出网络和默认模式网络。然而,除了更高的TAF可能性和反刍之外,行为数据显示,与HC组相比,MDD组在NegCP条件下的负面情绪更少,反应时间更长。此外,在 MDD 组中,双侧尾状核、左侧额叶下回/岛叶前部、普坦门和顶叶下部在 NegCP 条件下的激活度明显更高,这与 TAF 和反思呈正相关。这些研究结果表明,在TAF任务中,MDD患者可能会激活与维持高刺激显著性和习惯形成相关的不同脑区,而这些脑区是连接抑郁症TAF和反刍的重要神经相关区。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neural correlates of thought–action fusion and their associations with rumination in patients with major depressive disorder
Thought-action fusion (TAF) is the metacognitive belief that the power of thoughts can have real-life consequences, often inducing unpleasant inner experiences and recruiting coping strategies such as rumination. Therefore, this study aimed to investigate the neural correlates of TAF and their associations with rumination in depression. A total of 37 patients with major depressive disorder (MDD) and 37 healthy controls (HCs) underwent functional magnetic resonance imaging with a TAF induction task and psychological assessments. In the TAF induction task, participants were asked to read the name of a close person (CP) or neutral person (NP) in association with negative (Neg) TAF and neutral (Neu) control statements. In this study, our TAF induction task activated brain regions, including the salient and default-mode networks, in the MDD and HC groups. However, along with higher likelihood TAF and rumination, behavioral data showed less negative feelings and longer reaction times under the NegCP condition in the MDD group compared with the HC group. Furthermore, in the MDD group, significantly higher activation in the bilateral caudate nuclei, left inferior frontal gyrus/anterior insula, putamen, and inferior parietal lobule under the NegCP condition was positively correlated with TAF and reflection. These findings suggest that during the TAF task, patients with MDD may activate different brain areas associated with the maintenance of high stimulus saliency and habit formation, which are important neural correlates linking TAF and rumination in depression.
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来源期刊
Journal of psychiatric research
Journal of psychiatric research 医学-精神病学
CiteScore
7.30
自引率
2.10%
发文量
622
审稿时长
130 days
期刊介绍: Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;
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