生两个孩子可能最有利于女性的心理健康：来自英国生物数据库的证据。

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2024-10-15 DOI:10.1016/j.jad.2024.10.037

Jingfang Liu , Hao Sun , Ke Zhang , Ibrar Hussain , Yuying Wang , Hongpeng Sun , Zaixiang Tang

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引用次数: 0

摘要

背景：有关活产数量与躁郁症和重度抑郁症（BDMD）之间关系的研究十分有限。本研究旨在调查英国妇女的活产数与双相情感障碍和重度抑郁症之间的关系，为生育决策提供理论依据：这项横断面研究利用了英国生物库中超过 5.5 万名女性的数据。采用反概率治疗加权（IPTW）逻辑回归模型来减少偏差和混杂因素。多变量逻辑回归用于检验活产数与 BDMD 之间的关系，而限制性三次样条回归则用于分析活产数与 BDMD 之间的非线性关系。根据年龄、体重指数、自然流产、人工流产和自然流产进行了分组分析：IPTW-多元逻辑回归分析表明，活产是BDMD的独立保护因素。在 IPTW 多变量模型 4 中，活产组的几率比（OR）为 0.71（95 % CI 0.69-0.73，P 结论：我们的研究表明，活产是 BDMD 的独立保护因素：我们的研究表明，活产是预防 BDMD 的一个独立保护因素。在全球生育率下降和精神疾病发病率上升的背景下，这项研究具有特别重要的意义。它为妇女在全球生育率下降和精神健康问题增加的情况下做出生育决定提供了指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Having two children might be best for women's mental health: Evidence from UK Biobank

Background

Limited research has examined the association between the number of live births and bipolar disorder and major depression (BDMD). This study aims to investigate the relationship between the number of live births and BDMD among women in the UK, providing a theoretical basis for reproductive decision-making.

Methods

This cross-sectional study utilized data from >55,000 women in the UK Biobank. Inverse probability treatment weighting (IPTW) logistic regression models were employed to reduce bias and confounding. Multivariate logistic regression was applied to examine the relationship between live births and BDMD, while restricted cubic spline regression was utilized to analyze the nonlinear association between the number of live births and BDMD. Subgroup analyses were conducted, stratifying by age, BMI, spontaneous abortion, induced abortion, and spontaneous abortion.

Results

The IPTW-multivariate logistic regression analysis indicated that live births serve as an independent protective factor against BDMD. In IPTW-multivariate Model 4, the odds ratio (OR) for the live births group was 0.71 (95 % CI 0.69–0.73, P < 0.001). A significant nonlinear relationship was identified between the number of live births and the risk of BDMD. Additionally, it was found that women with two live births exhibited the lowest risk of BDMD.

Conclusion

Our study demonstrated that live births are an independent protective factor against BDMD. This research holds particular significance in the context of globally declining fertility rates and the increasing prevalence of mental disorders. It provides guidance for women on fertility decisions amid declining global fertility rates and increasing mental health issues.

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.