开始使用预混胰岛素的中国 2 型糖尿病患者的血糖监测状况及其影响因素：一项前瞻性真实世界研究。

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2024-10-16 DOI:10.1016/j.diabres.2024.111895

Si Chen , Jingyi Lu , Danfeng Peng , Fengjing Liu , Wei Lu , Wei Zhu , Yuqian Bao , Jian Zhou , Weiping Jia

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引用次数: 0

摘要

研究目的本研究旨在评估中国初用预混胰岛素患者自我血糖监测（SMBG）的现状及其影响因素：这是一项单臂、多中心、前瞻性的真实世界研究，共招募了8214名新使用预混胰岛素类似物的成年2型糖尿病（T2DM）患者。对每位患者随访 12 周，在第 1 周、第 4 周、第 8 周和第 12 周收集 SMBG 相关数据，在第 1 周和第 12 周收集糖化血红蛋白相关数据。主要结果是 12 周内 SMBG 的频率：结果：第 12 周时，83.3% 的参与者至少监测一次血糖，20.3% 的参与者继续每周监测血糖。前 4 周的平均监测频率为 4.78 次/周，12 周为 3.33 次/周。SMBG监测频率较高的患者血糖控制较好：这项研究发现，大多数 T2DM 患者会服用 SMBG，但随着时间的推移，坚持服用的次数会减少。中国 T2DM 患者对 SMBG 的依从性受年龄、胰岛素剂量、教育水平和糖尿病病程的影响。SMBG 有助于改善血糖控制。

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The status of blood glucose monitoring and its influencing factors in Chinese patients with type 2 diabetes initiating premixed insulin: A prospective real-world study

Objective

This study aimed to assess the current state of self-monitoring of blood glucose (SMBG) in Chinese patients initiating premixed insulin and its influential factors.

Research Design and Methods

This is a single-arm, multi-center, prospective real-world study enrolling a total of 8214 adult patients with type 2 diabetes mellitus (T2DM) newly initiated premixed insulin analogues. Each patient was followed up for 12 weeks, and the data related to SMBG was collected at week 1, week 4, week 8 and week 12, while data related to glycated hemoglobin were collected at week 1 and week 12. The primary outcome was the frequency of SMBG over 12 weeks.

Results

At week 12, 83.3 % monitored blood glucose at least once, while 20.3 % of participants continued SMBG every week. The average monitoring frequency was 4.78 times/week over the first 4 weeks and 3.33 times/week over 12 weeks. The patients with a higher frequency of SMBG had better control of blood glucose.

Conclusions

This study found that most T2DM patients would take SMBG but the adherence decreased over time. The adherence to SMBG in Chinese T2DM patients was influenced by age, insulin dosage, education level, and diabetes duration. SMBG benefited the improvement of glycemic control.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.