中枢神经系统疾病的单细胞 RNA 测序和空间转录组学研究进展。

IF 3.6 4区 医学 Q3 CELL BIOLOGY
Yuan Zhang, Teng Li, Guangtian Wang, Yabin Ma
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引用次数: 0

摘要

过去几年来,中枢神经系统(CNS)疾病的发病率持续上升。目前迫切需要有效的方法来提高中枢神经系统疾病的治愈率。然而,主要中枢神经系统疾病发生和发展的确切分子基础仍然难以捉摸。完整的分子图谱将有助于中枢神经系统疾病治疗策略的研究。单细胞 RNA 测序(scRNA-seq)和空间转录组学(ST)等新兴技术是探索中枢神经系统疾病的分子复杂性、细胞异质性和功能特异性的有力工具。本综述概述了有关中枢神经系统疾病(如慢性神经退行性疾病、急性中枢神经系统损伤等)的 scRNA-seq 和 ST 研究。这些研究通过发现与中枢神经系统疾病相关的新细胞类型或亚型、提出新的病理生理学机制、发现新的治疗靶点以及鉴定假定的生物标记物,为治疗和诊断中枢神经系统疾病提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advancements in Single-Cell RNA Sequencing and Spatial Transcriptomics for Central Nervous System Disease.

The incidence of central nervous system (CNS) disease has persistently increased over the last several years. There is an urgent need for effective methods to improve the cure rates of CNS disease. However, the precise molecular basis underlying the development and progression of major CNS diseases remains elusive. A complete molecular map will contribute to research on CNS disease treatment strategies. Emerging technologies such as single-cell RNA sequencing (scRNA-seq) and Spatial Transcriptomics (ST) are potent tools for exploring the molecular complexity, cell heterogeneity, and functional specificity of CNS disease. scRNA-seq and ST can provide insights into the disease at cellular and spatial transcription levels. This review presents a survey of scRNA-seq and ST studies on CNS diseases, such as chronic neurodegenerative diseases, acute CNS injuries, and others. These studies offer novel perspectives in treating and diagnosing CNS diseases by discovering new cell types or subtypes associated with the disease, proposing new pathophysiological mechanisms, uncovering novel therapeutic targets, and identifying putative biomarkers.

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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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