鼠李糖乳杆菌有助于缩短患有过敏性直肠结肠炎的母乳喂养婴儿的出血时间。

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Armen Malekiantaghi, Faezeh Ghanaati, Hosein Shabani-Mirzaee, Mamak Shariat, Sayed-Yousef Mojtahedi, Kambiz Eftekhari
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引用次数: 0

摘要

背景:牛奶蛋白过敏(CMPA)是婴儿最常见的食物过敏。目前的治疗标准(SOC)包括在 2-4 周内从婴儿和母亲的饮食中去除过敏原。本研究旨在评估鼠李糖乳杆菌(Ramnoflor)在缩短这些婴儿出血时间方面的效果。研究方法这项随机临床试验是在 Bahrami 儿童医院进行的,对象是被诊断为 CMPA 且隐血 (OB) 检测呈阳性的母乳喂养婴儿。患者被随机分配到对照组或病例组。所有患者均接受 SOC 治疗,病例组接受 Ramnoflor 治疗,对照组接受安慰剂治疗。数据记录在检查表上,研究期间对患儿进行了三次随访和探视,每次探视都进行了一次潜血评估。研究结果研究共招募了 48 名婴儿。在病例组的婴儿中,有 4 例(8.3%)在第五天的产前检查中呈阳性。但是,在第 14 天和第 30 天没有阳性病例。与对照组相比,接受益生菌治疗的患儿在第五天的转阴率明显降低(p < 0.001)。在第 14 天和第 30 天,各组均未出现 OB 检测呈阳性的病例,且各组之间未发现明显差异。结论与对照组相比,在 SOC 治疗中添加鼠李糖可缩短 CMPA 患儿直肠出血的持续时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lactobacillus rhamnosus Helps to Reduce the Duration of Bleeding in Breastfed Infants with Allergic Proctocolitis.

Background: Cow's milk protein allergy (CMPA) is the most common food allergy in infants. The current standard of care (SOC) involves eliminating the allergen from both the infant's and mother's diet for 2-4 weeks. The purpose of this study is to assess the effectiveness of Lactobacillus rhamnosus (Ramnoflor) in reducing the duration of bleeding in these infants. Methods: This randomized clinical trial was conducted at Bahrami Children's Hospital on breastfed infants who were diagnosed with CMPA and had a positive occult blood (OB) test. Patients were randomly assigned to either the control or case groups. All patients received SOC therapy, with the case group receiving Ramnoflor and the control group receiving a placebo. Data were recorded on the checklist, and the children were followed and visited three times during the study, with an OB assessment at each visit. Results: The study enrolled 48 infants. Among the infants in the case group, the OB test was positive in four cases (8.3%) on the fifth day. However, there were no positive cases on the 14th and 30th days. The prevalence of this test was significantly lower in patients who received probiotics compared to the control group on the fifth day (p < 0.001). There were no positive OB tests on the 14th and 30th days in any of the groups, and no significant difference was observed between the groups. Conclusion: The addition of L. rhamnosus to SOC therapy led to a decrease in the duration of rectal bleeding in infants with CMPA compared to the control group.

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来源期刊
Breastfeeding Medicine
Breastfeeding Medicine OBSTETRICS & GYNECOLOGY-PEDIATRICS
CiteScore
4.20
自引率
11.10%
发文量
130
审稿时长
6-12 weeks
期刊介绍: Breastfeeding Medicine provides unparalleled peer-reviewed research, protocols, and clinical applications to ensure optimal care for mother and infant. The Journal answers the growing demand for evidence-based research and explores the immediate and long-term outcomes of breastfeeding, including its epidemiologic, physiologic, and psychological benefits. It is the exclusive source of the Academy of Breastfeeding Medicine protocols. Breastfeeding Medicine coverage includes: Breastfeeding recommendations and protocols Health consequences of artificial feeding Physiology of lactation and biochemistry of breast milk Optimal nutrition for the breastfeeding mother Breastfeeding indications and contraindications Managing breastfeeding discomfort, pain, and other complications Breastfeeding the premature or sick infant Breastfeeding in the chronically ill mother Management of the breastfeeding mother on medication Infectious disease transmission through breast milk and breastfeeding The collection and storage of human milk and human milk banking Measuring the impact of being a “baby-friendly” hospital Cultural competence and cultural sensitivity International public health issues including social and economic issues.
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