8q染色体的增益和EZH2的高表达可预测中国葡萄膜黑色素瘤患者的不良预后。

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Asia-Pacific Journal of Ophthalmology Pub Date : 2024-09-01 DOI:10.1016/j.apjo.2024.100108

Lingyu Zhang , Hui Pan , Yiran Yao , Xiang Gu , Tongxin Ge , Junqi Cui , Peiwei Chai , Xiaofang Xu , Renbing Jia , Ai Zhuang , Xianqun Fan

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引用次数: 0

摘要

目的：探讨在中国人群中预测葡萄膜黑色素瘤不良预后的风险因素，特别强调单体3、8q增益和EZH2染色：研究回顾了2012年至2021年的89例葡萄膜黑色素瘤患者。收集并分析了临床和病理记录。分别对45、54和57例患者进行了EZH2、3单体和8q增殖的免疫组化染色。生存率通过 Kaplan-Meier 分析和对数秩检验进行评估。结果显示，中位随访时间为44个月：中位随访时间为 44 个月。结果：中位随访时间为44个月，共有16%的患者出现远处转移并死于疾病相关原因。一年和三年的疾病特异性生存率分别为96.6%和88.4%，远处转移率分别为7.9%和12%。单变量Cox回归分析显示，年龄（HR：1.04）、肿瘤最大基底直径（HR：1.21）、肿瘤厚度（HR：1.21）、睫状体受累（HR：3.50）、AJCC分期（HR：5.68）、上皮样细胞类型（HR：7.71）、8q增益（HR：7.48）和EZH2高表达（HR：6.09）与远处转移相关。8q增益与上皮样细胞类型和肿瘤较厚有关，而EZH2与上皮样细胞类型相关。结论：EZH2和8q增益与上皮样细胞类型和肿瘤厚度相关，而EZH2与上皮样细胞类型相关，单体3与其他因素无明显相关性：结论：在计算中国葡萄膜黑色素瘤患者的不良预后时，可将EZH2和8q基因增殖考虑在内。单体3对远处转移无显著影响，但这可能是由于样本量较小。

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Gain of chromosome 8q and high expression of EZH2 may predict poor prognosis in Chinese patients with uveal melanoma

Purpose

To explore risk factors predicting poor prognosis of uveal melanoma in a Chinese population, with specific emphasis on monosomy 3, 8q gain, and EZH2 staining.

Methods

Eighty-nine patients with uveal melanoma from 2012 to 2021 were reviewed. Clinical and pathological records were collected and analyzed. Immunohistochemical staining of EZH2, monosomy 3 and 8q gain were respectively conducted in 45, 54, and 57 cases. Survival was evaluated by Kaplan–Meier analysis and log-rank test. Cox proportional hazard regressions were employed to predict risk factors of distant metastasis.

Results

The median follow-up was 44 months. Altogether, 16 % of patients developed distant metastases and died from disease-related causes. Disease-specific survival at one and three years was 96.6 % and 88.4 % while distant metastasis rates were 7.9 % and 12 %. Univariate Cox regression analysis revealed that age (HR: 1.04), tumor largest basal diameter (HR: 1.21), tumor thickness (HR: 1.21), ciliary body involvement (HR: 3.50), AJCC stage (HR: 5.68), epithelioid cell type (HR: 7.71), 8q gain (HR: 7.48), and high expression of EZH2 (HR: 6.09) were associated with distant metastasis. 8q gain was associated with epithelioid cell type and thicker tumor while EZH2 was correlated with epithelioid cell type. Monosomy 3 lacked a significant correlation with other factors.

Conclusion

EZH2 and 8q gain could be taken into consideration when calculating poor prognosis in Chinese patients with uveal melanoma. Monosomy 3 showed no significance in distant metastasis, but this may be due to a small sample size.

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来源期刊

Asia-Pacific Journal of Ophthalmology OPHTHALMOLOGY-

CiteScore

8.10

自引率

18.20%

发文量

197

审稿时长

6 weeks

期刊介绍： The Asia-Pacific Journal of Ophthalmology, a bimonthly, peer-reviewed online scientific publication, is an official publication of the Asia-Pacific Academy of Ophthalmology (APAO), a supranational organization which is committed to research, training, learning, publication and knowledge and skill transfers in ophthalmology and visual sciences. The Asia-Pacific Journal of Ophthalmology welcomes review articles on currently hot topics, original, previously unpublished manuscripts describing clinical investigations, clinical observations and clinically relevant laboratory investigations, as well as .perspectives containing personal viewpoints on topics with broad interests. Editorials are published by invitation only. Case reports are generally not considered. The Asia-Pacific Journal of Ophthalmology covers 16 subspecialties and is freely circulated among individual members of the APAO’s member societies, which amounts to a potential readership of over 50,000.