全国炎症性肠病患者队列中硫嘌呤诱发严重骨髓抑制的发生率。

IF 8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

American Journal of Gastroenterology Pub Date : 2024-10-18 DOI:10.14309/ajg.0000000000003141

Nabeel Khan, Dhruvan Patel, Ramaswamy Sundararajan

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引用次数: 0

摘要

简介：有关炎症性肠病（IBD）患者中严重硫嘌呤（TP）诱发骨髓抑制（TIM）的数据很少：关于炎症性肠病（IBD）患者中严重硫嘌呤（TP）诱导的骨髓抑制（TIM）发生率的数据很少：利用退伍军人事务医疗保健系统，我们确定了治疗前硫嘌呤S-甲基转移酶（TPMT）水平正常、接受硫嘌呤类药物治疗6个月并出现严重TIM的IBD患者：在 73392 名 IBD 患者中，14760 人接受了硫嘌呤 S-甲基转移酶治疗，2823 人的 TPMT 水平正常。严重 TIM 的发病率为每 1000 患者年 1.25 例：讨论：严重 TIM 的发生率非常低，这让人质疑是否有必要对服用 TPs 的 IBD 患者进行频繁的长期 CBC 监测。

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Incidence of thiopurine induced severe myelosuppression in a nationwide cohort of inflammatory bowel disease patients.

Introduction: There is paucity of data on the incidence of severe thiopurine (TP)-induced myelosuppression (TIM) among inflammatory bowel disease (IBD) patients.

Methods: Utilizing the Veterans Affairs Healthcare system we identified IBD patients with normal pre-treatment thiopurine S-methyltransferase(TPMT) levels who received TPs for 6 months and developed severe TIM.

Results: Among 73,392 IBD patients, 14,760 had received TPs, and 2823 had a normal TPMT level. The incidence rate of severe TIM was 1.25 per 1000 patient-years.

Discussion: The incidence of severe TIM was very low, calling into question the necessity of frequent long-term CBC monitoring among IBD patients on TPs.

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来源期刊

American Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

11.40

自引率

5.10%

发文量

458

审稿时长

12 months

期刊介绍： Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.