磷脂酰肌醇/磷脂酸脂质转运体 PITPNC1 在生理学和病理学中的扩展功能。

Q1 Biochemistry, Genetics and Molecular Biology

Advances in biological regulation Pub Date : 2024-10-09 DOI:10.1016/j.jbior.2024.101056

Shamshad Cockcroft

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引用次数: 0

摘要

PITPNC1 是最后一种被确认的 PITPs，其特征是磷脂酰肌醇和磷脂酸的结合蛋白。在哺乳动物中，PITPNC1 以两种剪接变体的形式表达，而在斑马鱼中则由两个独立的基因表达。这两种剪接变体有不同的表达谱，其中长剪接变体在大脑中的作用突出。目前已经确定了几种生理功能，包括神经元和新陈代谢功能。PITPNC1 在癌症中也发挥着重要作用，并被确定为 2 型糖尿病的风险因素。在此，我们回顾了我们目前对 PITPNC1 在细胞生理学和病理学中作用的理解。

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Expanding functions of the phosphatidylinositol/phosphatidate lipid transporter, PITPNC1 in physiology and in pathology.

PITPNC1 was the last of the PITPs to be identified and has been characterized as a binding protein for phosphatidylinositol and phosphatidate. In mammals, PITPNC1 is expressed as two splice variants whilst in zebrafish is expressed from two separate genes. The two splice variants have different expression profiles with the long splice variant having a prominent role in the brain. Several physiological functions have been identified including neuronal and metabolic functions. PITPNC1 also plays a significant role in cancer and has been identified as a risk factor in type 2 diabetes. Here, we review our current understanding of PITPNC1 in cell physiology and pathology.

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来源期刊

Advances in biological regulation Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

8.90

自引率

0.00%

发文量

审稿时长

17 days