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The interactions of AuNPs with electromagnetic radiation (e.g., visible-near-infrared, X-rays) can be used for photothermal therapy and radiation therapy, through heat generated from light absorption and emission of Auger electrons, respectively. The subsequent expansion and high X-ray attenuation from AuNPs can be used for enhancing contrast for tumor detection (e.g., using photoacoustic, computed tomography imaging). Multi-functionality can be further extended through covalent/non-covalent functionalization, for loading additional imaging/therapeutic molecules for combination therapy and multimodal imaging. 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引用次数: 0
摘要
癌症的诊断和治疗往往具有挑战性,需要更具吸引力的选择。某些类型的癌症比其他类型的癌症更具侵袭性,许多癌症的症状并不明显,尤其是在早期阶段。纳米技术为癌症检测、治疗和监测提供了高灵敏度、高特异性和多模式能力。尤其是金属纳米粒子(NPs),如金纳米粒子(AuNPs),对于对生物成像和治疗感兴趣的研究人员来说是一种极具吸引力的纳米系统。AuNPs 的大小、形状和表面可以通过引入配体和表面电荷等方式进行修饰,以提高在癌细胞中的靶向性和蓄积性。AuNPs 与电磁辐射(如可见光-近红外和 X 射线)的相互作用可分别通过光吸收和奥杰电子发射产生的热量用于光热疗法和放射治疗。AuNPs 随后产生的膨胀和高 X 射线衰减可用于增强肿瘤检测的对比度(例如,利用光声学和计算机断层扫描成像)。还可通过共价/非共价功能化进一步扩展其多功能性,装载额外的成像/治疗分子,用于联合治疗和多模式成像。为了涵盖设计和使用 AuNPs 进行癌症治疗的重要方面,本综述重点介绍对 AuNPs 十分重要的合成、功能化和表征方法,并介绍 AuNPs 的独特性质及其在癌症治疗中的不同应用。
Multifunctional gold nanoparticles for cancer theranostics.
The diagnosis and treatment of cancer can often be challenging requiring more attractive options. Some types of cancers are more aggressive than others and symptoms for many cancers are subtle, especially in the early stages. Nanotechnology provides high sensitivity, specificity and multimodal capability for cancer detection, treatment and monitoring. In particular, metal nanoparticles (NPs) such as gold nanoparticles (AuNPs) are attractive nanosystems for researchers interested in bioimaging and therapy. The size, shape and surface of AuNPs can be modified for improving targeting and accumulation in cancer cells, for example through introduction of ligands and surface charge. The interactions of AuNPs with electromagnetic radiation (e.g., visible-near-infrared, X-rays) can be used for photothermal therapy and radiation therapy, through heat generated from light absorption and emission of Auger electrons, respectively. The subsequent expansion and high X-ray attenuation from AuNPs can be used for enhancing contrast for tumor detection (e.g., using photoacoustic, computed tomography imaging). Multi-functionality can be further extended through covalent/non-covalent functionalization, for loading additional imaging/therapeutic molecules for combination therapy and multimodal imaging. In order to cover the important aspects for designing and using AuNPs for cancer theranostics, this review focuses on the synthesis, functionalization and characterization methods that are important for AuNPs, and presents their unique properties and different applications in cancer theranostics.
3 BiotechAgricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)
CiteScore
6.00
自引率
0.00%
发文量
314
期刊介绍:
3 Biotech publishes the results of the latest research related to the study and application of biotechnology to:
- Medicine and Biomedical Sciences
- Agriculture
- The Environment
The focus on these three technology sectors recognizes that complete Biotechnology applications often require a combination of techniques. 3 Biotech not only presents the latest developments in biotechnology but also addresses the problems and benefits of integrating a variety of techniques for a particular application. 3 Biotech will appeal to scientists and engineers in both academia and industry focused on the safe and efficient application of Biotechnology to Medicine, Agriculture and the Environment.