Fusarium oxysporum 的一种新型分泌蛋白通过抑制植物体内的 PR-5 蛋白促进感染

IF 6 1区 生物学 Q1 PLANT SCIENCES
Hengwei Qian, Zhiliang Xiao, Lirui Cheng, Ruimei Geng, Yan Ma, Yanxiao Bi, Wenxing Liang, Aiguo Yang
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引用次数: 0

摘要

镰刀菌是一种重要的土传真菌病原体,可引起严重的镰刀菌枯萎病,在感染过程中会分泌多种效应物。在这项研究中,我们发现了一种新型富半胱氨酸分泌蛋白 FolSCP1,它含有未知的蛋白功能域。在此,我们将 FolSCP1 鉴定为一种分泌型毒力因子,它通过抑制多种植物防御反应来促进病原体感染寄主植物。FolSCP1 与致病相关 5(PR-5)蛋白 SlPR5(番茄植物对多种番茄病原体免疫的正调控因子)相互作用,并有效削弱了番茄 PR-5 蛋白的抗真菌活性。FoSCP1 是 FolSCP1 的同源物,由感染烟草的 F. oxysporum 分离物分泌,以烟草 PR-5 蛋白 NtPR5 为靶标,抑制植物进一步感染的防御能力。总之,我们的研究揭示了一种真菌毒力策略,即草孢子菌分泌的效应物通过与寄主植物的 PR-5 蛋白结合并抑制其生物活性来干扰植物免疫,从而促进真菌感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Novel Secreted Protein of Fusarium oxysporum Promotes Infection by Inhibiting PR-5 Protein in Plant.

Fusarium oxysporum, an important soilborne fungal pathogen that causes serious Fusarium wilt disease, secretes diverse effectors during the infection. In this study, we identified a novel secreted cysteine-rich protein, FolSCP1, which contains unknown protein functional domain. Here, we characterized FolSCP1 as a secreted virulence factor that promotes the pathogen infection of host plants by inhibiting diverse plant defence responses. FolSCP1 interacted with the pathogenesis-related 5 (PR-5) protein SlPR5, a positive regulator of tomato plant immunity against multiple tomato pathogens, and effectively attenuated the antifungal activity of the tomato PR-5 protein. FoSCP1, a homologue of FolSCP1, was secreted by a F. oxysporum isolate from infected tobacco and targeted the tobacco PR-5 protein NtPR5 to suppress plant defence for further infection. In summary, our study revealed a fungal virulence strategy in which F. oxysporum secrete effectors that interfere with plant immunity by binding to the PR-5 protein of the host plant and inhibiting its biological activity, thereby promoting fungal infection.

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来源期刊
Plant, Cell & Environment
Plant, Cell & Environment 生物-植物科学
CiteScore
13.30
自引率
4.10%
发文量
253
审稿时长
1.8 months
期刊介绍: Plant, Cell & Environment is a premier plant science journal, offering valuable insights into plant responses to their environment. Committed to publishing high-quality theoretical and experimental research, the journal covers a broad spectrum of factors, spanning from molecular to community levels. Researchers exploring various aspects of plant biology, physiology, and ecology contribute to the journal's comprehensive understanding of plant-environment interactions.
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