在 t(1;6)(p35.3;p25.2) 染色体易位的 CLL 患者中发现 RCC1::IRF4 融合基因。

IF 5.1 2区医学 Q1 HEMATOLOGY

British Journal of Haematology Pub Date : 2024-10-15 DOI:10.1111/bjh.19821

Anna E Pula, Tadeusz Robak

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引用次数: 0

摘要

Jayne 等人对慢性淋巴细胞白血病患者的 t(1;6)(p35.3;p25.2)染色体易位进行了分子鉴定。他们指出，该易位涉及染色体 6p25.2 上的干扰素调节因子 4（IRF4）编码基因和染色体 1p35.3 上的染色体凝聚调节因子 1（RCC1）基因。这种易位可能具有重要的预后价值。相关评论Jayne et al. 染色体易位 t(1;6)(p35.3;p25.2)，在慢性淋巴细胞白血病中复发，导致 RCC1::IRF4 融合。Doi: 10.1111/bjh.19790.

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The discovery of the RCC1::IRF4 Fusion in CLL patients with t(1;6)(p35.3;p25.2) chromosomal translocation.

Jayne et al. provide a molecular characterization of the t(1;6)(p35.3;p25.2) chromosomal translocation in patients with chronic lymphocytic leukaemia. They indicate that this translocation involves the gene encoding interferon regulatory factor 4 (IRF4) on chromosome 6p25.2 with the regulator of chromosome condensation 1 (RCC1) gene on chromosome 1p35.3. This translocations may have important prognostic value. Commentary on: Jayne et al. The chromosomal translocation t(1;6)(p35.3;p25.2), recurrent in chronic lymphocytic leukaemia leads to RCC1::IRF4 fusion. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19790.

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来源期刊

British Journal of Haematology 医学-血液学

CiteScore

8.60

自引率

4.60%

发文量

565

审稿时长

1 months

期刊介绍： The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.