用于疾病预防、诊断和治疗的可降解生物医学聚合物的最新进展。

IF 5.5 2区 化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biomacromolecules Pub Date : 2024-11-11 Epub Date: 2024-10-17 DOI:10.1021/acs.biomac.4c01193
Siting Zhang, Huapan Fang, Huayu Tian
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引用次数: 0

摘要

生物医用聚合物在预防、诊断和治疗疾病方面发挥着关键作用,应用范围十分广泛。生物医用聚合物具有来源丰富、生物相容性好、可改性强等独特优势,是药物输送、生物医学成像和组织工程的理想生物材料。然而,传统的生物医学聚合物在体内降解性差,增加了生物蓄积和潜在毒性的风险。为解决这些问题,可降解生物医学聚合物可作为生物医学的替代策略。可降解生物医用聚合物可有效缓解体内生物蓄积性,并在疾病治疗中有效减轻患者负担。本综述全面介绍了生物医用聚合物的分类和特性,以及可降解生物医用聚合物在各种疾病中的最新研究进展。通过对可降解生物医用高分子材料的分类、性能和应用的深入分析,旨在为促进可降解生物医用高分子材料的基础研究和临床转化提供有力的指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Advances in Degradable Biomedical Polymers for Prevention, Diagnosis and Treatment of Diseases.

Biomedical polymers play a key role in preventing, diagnosing, and treating diseases, showcasing a wide range of applications. Their unique advantages, such as rich source, good biocompatibility, and excellent modifiability, make them ideal biomaterials for drug delivery, biomedical imaging, and tissue engineering. However, conventional biomedical polymers suffer from poor degradation in vivo, increasing the risks of bioaccumulation and potential toxicity. To address these issues, degradable biomedical polymers can serve as an alternative strategy in biomedicine. Degradable biomedical polymers can efficiently relieve bioaccumulation in vivo and effectively reduce patient burden in disease management. This review comprehensively introduces the classification and properties of biomedical polymers and the recent research progress of degradable biomedical polymers in various diseases. Through an in-depth analysis of their classification, properties, and applications, we aim to provide strong guidance for promoting basic research and clinical translation of degradable biomedical polymers.

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来源期刊
Biomacromolecules
Biomacromolecules 化学-高分子科学
CiteScore
10.60
自引率
4.80%
发文量
417
审稿时长
1.6 months
期刊介绍: Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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